Meta-Analysis of the Potential Role of miRNA-21 in Cardiovascular System Function Monitoring

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 6
• Main Authors: Kędziora Kornatowska, Kornelia, Recchia, Emeline, Jeanniere, Caroline, Bracha, Marietta, Krzywińska, Olga, Kozakiewicz, Mariusz
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analysis; Angiogenesis; Antisense RNA; Apoptosis; Biomarkers; Biomedical research; Biosynthesis; Body fluids; Cardiovascular diseases; Cardiovascular Diseases - genetics; Cardiovascular system; Cardiovascular System - metabolism; Cell differentiation; Cell migration; Endothelial cells; Endothelium; Enzymes; Fibroblasts; Gene expression; Genes; Genetic Markers; Growth factors; Heart attack; Heart attacks; Humans; Ischemia; Kinases; Meta-analysis; Metabolism; MicroRNA; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Mortality; mRNA; Myocardial infarction; Physiological aspects; Promoter Regions, Genetic; Proteins; Review; Ribonucleic acid; RNA; RNA, Messenger - genetics; RNA, Messenger - metabolism; Signal transduction; Stem cells
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2020/4525410

MicroRNAs (miRNAs) are short and noncoding RNA fragments that bind to the messenger RNA. They have different roles in many physiological or pathological processes. MicroRNA-21, one of the first miRNAs discovered, is encoded by the MIR21 gene and is located on the chromosomal positive strand 17q23.2. MicroRNA-21 is transcribed by polymerase II and has its own promoter sequence, although it is in an intron. It is intra- and extracellular and can be found in many body fluids, alone or combined with another molecule. It regulates many signalling pathways and therefore plays an important role in the cardiovascular system. Indeed, it is involved in the differentiation and migration of endothelial cells and angiogenesis. It contributes to the reconstruction of a myocardial infarction, and it can also act as a cellular connector or as an antagonist to cardiac cell apoptosis. By playing all these roles, it can be interesting to use it as a biomarker, especially for cardiovascular diseases.