Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori
Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth...
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Published in | Evidence-based complementary and alternative medicine Vol. 2018; no. 2018; pp. 1 - 10 |
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Main Authors | , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Cairo, Egypt
Hindawi Publishing Corporation
01.01.2018
Hindawi John Wiley & Sons, Inc Hindawi Limited |
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Abstract | Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori-infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti-H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting. |
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AbstractList | Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori-infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti-H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting. Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori -infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti- H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti- H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting. Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in -infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti- activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti- activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other eradication medications in the clinical setting. |
Audience | Academic |
Author | Meng, FanDong Zhang, Shutian Guo, Shuilong Zhu, Shengtao Zhao, Xin Xu, HuFeng Wang, QinQin Zhang, Yan Sun, YiLin Li, Lei Wang, Yongjun |
AuthorAffiliation | 2 Department of Digestive Diseases, Affiliated Hospital for Wei Fang Medical University, Wei Fang 261031, China 4 Department of Ultrapathology of Beijing Neurosurgical Institute, Beijing 100050, China 5 Department of Ultrapathology of Beijing Neurosurgical Institute, Affiliated Bayi Brain Hospital, Army General Hospital of PLA, Beijing 100700, China 6 The Animal Experiment Center of Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China 1 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China 3 Key Laboratory of Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China |
AuthorAffiliation_xml | – name: 1 Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, National Clinical Research Center for Digestive Diseases, Beijing Digestive Disease Center, Beijing Key Laboratory for Precancerous Lesion of Digestive Diseases, Beijing 100050, China – name: 5 Department of Ultrapathology of Beijing Neurosurgical Institute, Affiliated Bayi Brain Hospital, Army General Hospital of PLA, Beijing 100700, China – name: 3 Key Laboratory of Safety Risk Assessment of Ministry of Health, China National Center for Food Safety Risk Assessment, Beijing 100021, China – name: 6 The Animal Experiment Center of Beijing Friendship Hospital, Capital Medical University, Beijing 100050, China – name: 2 Department of Digestive Diseases, Affiliated Hospital for Wei Fang Medical University, Wei Fang 261031, China – name: 4 Department of Ultrapathology of Beijing Neurosurgical Institute, Beijing 100050, China |
Author_xml | – sequence: 1 fullname: Xu, HuFeng – sequence: 2 fullname: Zhang, Shutian – sequence: 3 fullname: Wang, QinQin – sequence: 4 fullname: Sun, YiLin – sequence: 5 fullname: Zhao, Xin – sequence: 6 fullname: Wang, Yongjun – sequence: 7 fullname: Guo, Shuilong – sequence: 8 fullname: Zhu, Shengtao – sequence: 9 fullname: Meng, FanDong – sequence: 10 fullname: Li, Lei – sequence: 11 fullname: Zhang, Yan |
BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29636776$$D View this record in MEDLINE/PubMed |
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CitedBy_id | crossref_primary_10_1002_smll_202308286 crossref_primary_10_13105_wjma_v8_i2_98 crossref_primary_10_1155_2020_9154738 crossref_primary_10_1155_2020_2679034 crossref_primary_10_3389_fmicb_2022_1033201 crossref_primary_10_12998_wjcc_v9_i35_10781 |
Cites_doi | 10.1007/s100960050412 10.1136/gutjnl-2016-312288 10.1007/bf03259915 10.1159/000350719 10.1111/hel.12311 10.1039/c4nr01405g 10.1046/j.1365-2036.1996.22163000.x 10.1186/s13099-016-0091-7 10.1007/BF02098030 10.2147/IJNRD.S54818 10.1111/j.1523-5378.2010.00788.x 10.1016/S0016-5085(97)70155-0 10.1271/bbb.120690 10.1021/ja2013278 10.1111/j.1742-7843.2005.pto_973132.x 10.1177/002215540004801107 10.3748/wjg.v16.i40.5118 10.23736/S1121-421X.17.02369-8 10.1111/apt.13346 10.1136/bmj.2.6094.1052 10.1136/gut.2009.192757 10.1111/j.1523-5378.2010.00779.x 10.1111/hel.12332 10.1371/journal.pone.0035072 10.1159/000199555 10.3168/jds.S0022-0302(82)82260-1 10.1016/j.jep.2012.03.001 |
ContentType | Journal Article |
Copyright | Copyright © 2018 Lei Li et al. COPYRIGHT 2018 John Wiley & Sons, Inc. Copyright © 2018 Lei Li et al.; This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2018 Lei Li et al. 2018 |
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Snippet | Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However,... Bismuth‐containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However,... |
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SubjectTerms | Accumulation Acorus Antibacterial agents Antibiotics Atomic beam spectroscopy Bismuth Bismuth compounds Clarithromycin Comparative analysis Developing countries Disease Drug resistance Drugs Fluorescence Fluorescence spectroscopy Gastric cancer Granular materials Helicobacter infections Helicobacter pylori Herbal medicine Herbs Hospitals Infections Kidneys Laboratory animals LDCs Liver Medicinal herbs Medicinal plants Medicine, Botanic Medicine, Herbal Metronidazole Rats Risk assessment Safety Ulcers |
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Title | Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori |
URI | https://search.emarefa.net/detail/BIM-1155153 https://dx.doi.org/10.1155/2018/4320219 https://www.ncbi.nlm.nih.gov/pubmed/29636776 https://www.proquest.com/docview/2002926795 https://search.proquest.com/docview/2024016339 https://pubmed.ncbi.nlm.nih.gov/PMC5832115 |
Volume | 2018 |
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