Efficacy and Safety of Wei Bi Mei, a Chinese Herb Compound, as an Alternative to Bismuth for Eradication of Helicobacter pylori

• Published in: Evidence-based complementary and alternative medicine Vol. 2018; no. 2018; pp. 1 - 10
• Main Authors: Xu, HuFeng, Zhang, Shutian, Wang, QinQin, Sun, YiLin, Zhao, Xin, Wang, Yongjun, Guo, Shuilong, Zhu, Shengtao, Meng, FanDong, Li, Lei, Zhang, Yan
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 01.01.2018; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Accumulation; Acorus; Antibacterial agents; Antibiotics; Atomic beam spectroscopy; Bismuth; Bismuth compounds; Clarithromycin; Comparative analysis; Developing countries; Disease; Drug resistance; Drugs; Fluorescence; Fluorescence spectroscopy; Gastric cancer; Granular materials; Helicobacter infections; Helicobacter pylori; Herbal medicine; Herbs; Hospitals; Infections; Kidneys; Laboratory animals; LDCs; Liver; Medicinal herbs; Medicinal plants; Medicine, Botanic; Medicine, Herbal; Metronidazole; Rats; Risk assessment; Safety; Ulcers; China; Beijing China
• ISSN: 1741-427X; 1741-4288
• DOI: 10.1155/2018/4320219

Bismuth-containing quadruple therapy has been recommended as the first line of treatment in areas of high clarithromycin or metronidazole resistance. However, safety concerns of bismuth agents have long been raised. We first assessed the efficacy and safety of Wei Bi Mei granules, which are bismuth compounds consisting of three synthetic drugs and five medicinal herbs, compared to bismuth aluminate and colloidal bismuth subcitrate (CBS) in H. pylori-infected mouse model. We then used atomic fluorescence spectroscopy and autometallography to measure the accumulation of three bismuth agents in the brain, heart, liver, and kidneys in adult Sprague-Dawley rats. We also evaluated the safety of bismuth agents by conducting clinical biochemistry tests in blood samples of experimental animals. Wei Bi Mei granules exhibited the highest efficacy of anti-H. pylori activity and yielded the lowest bismuth accumulation when compared to CBS and bismuth aluminate. Our findings show that Wei Bi Mei granules are a safe Chinese medicinal herb with potent anti-H. pylori activity and can be considered as an alternative to current bismuth compounds. Thus, Wei Bi Mei granules merit further evaluation, particularly with regard to efficacy and safety when they are combined with other H. pylori eradication medications in the clinical setting.