The Pungent and Hot Chinese Herbs Cause Heat Syndrome in Rats by Affecting the Regulatory T Cells

Heat syndrome is a folk saying in China, which is used to describe people with symptoms such as aphtha, oral ulcer, glossitis, swelling and aching of gingiva, and dry eye. Aconitum carmichaelii Debx. (A), Zingiber officinale Rosc. (Z), and Cinnamomum cassia Presl (C) are the representatives of punge...

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Published inEvidence-based complementary and alternative medicine Vol. 2019; no. 2019; pp. 1 - 9
Main Authors Fan, Yongsheng, Xie, Guanqun, Xu, Li, Wu, Dehong, Zhou, Jia
Format Journal Article
LanguageEnglish
Published Cairo, Egypt Hindawi Publishing Corporation 2019
Hindawi
John Wiley & Sons, Inc
Hindawi Limited
Subjects
CD25 antigen
CD4 antigen
Chinese medicine
Cytokines
Drug dosages
Flow cytometry
Foxp3 protein
Glossitis
Heat
Herbal medicine
Herbs
Immunology
Immunoregulation
Inflammatory bowel disease
Interleukin 10
Laboratory animals
Lupus
Lymphocytes
Lymphocytes T
mRNA
Polymerase chain reaction
Spleen
Thymus
China
United States > US
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Summary:Heat syndrome is a folk saying in China, which is used to describe people with symptoms such as aphtha, oral ulcer, glossitis, swelling and aching of gingiva, and dry eye. Aconitum carmichaelii Debx. (A), Zingiber officinale Rosc. (Z), and Cinnamomum cassia Presl (C) are the representatives of pungent and hot Chinese herbs which may cause heat syndrome. In order to explore the mechanism of pungent herbs-induced heat syndrome, rats were treated with AZC extracts at different concentrations and at different time periods. A series of cytokines were determined using the cytokine antibody array; some immunosuppressive cytokines, including TGF-β, IL-10, and IL-35, significantly increased in AZC group as compared with control group. Higher mRNA expressions of Foxp3, TGF-β, IL-10, and IL-35 were found in the spleen and thymus of rats after treatment for 18 days based on RT-PCR. Flow cytometry result revealed that the percentage of CD4+CD25+ Treg cells and Foxp3+CD4+CD25+ Treg cells in spleen lymphocytes showed an increasing trend from the 3rd day to the 18th day after treatment with middle dose of AZC extracts. It is speculated that extracts of AZC herbs may affect the development of heat syndrome by influencing Treg cells and immunosuppressive cytokines.
Bibliography:ObjectType-Article-1
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Academic Editor: Yuewen Gong
ISSN:1741-427X
1741-4288
DOI:10.1155/2019/9824906