Diphenyl Ditelluride: Redox-Modulating and Antiproliferative Properties

• Published in: Oxidative medicine and cellular longevity Vol. 2019; no. 2019; pp. 1 - 14
• Main Authors: Pêgas Henriques, João Antonio, Pessoa, Claudia, Vargas, José Eduardo, dos Santos Silveira, Priscila, de Oliveira, Iuri M., Guecheva, Temenouga Nikolova, Juchem, André Luiz Mendes, Trindade, Cristiano, Puga, Renato
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2019; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Analysis; Antioxidants; Antioxidants - pharmacology; Antioxidants - therapeutic use; Benzene Derivatives - pharmacology; Benzene Derivatives - therapeutic use; Bioinformatics; Brain research; Cancer; Cells; Chemotherapy; Cytotoxicity; Deoxyribonucleic acid; DNA; DNA damage; Drug resistance; Humans; Hydrogen peroxide; Lipid peroxidation; Medical research; Organometallic Compounds - pharmacology; Organometallic Compounds - therapeutic use; Oxidation-Reduction; Oxidative stress; Proteins; Quantum dots; Review; Selenium; Sulfur; Tellurium - chemistry; Toxicology; Brazil
• ISSN: 1942-0900; 1942-0994
• DOI: 10.1155/2019/2510936

Tellurium is a rare element that has been regarded as a toxic, nonessential element, and its biological role is not clearly established. In addition, the biological effects of elemental tellurium and some of its organic and inorganic derivatives have been studied, leading to a set of interesting and promising applications. Diphenyl ditelluride (DPDT), an organic tellurium derivate, showed antioxidant, antigenotoxic, antimutagenic, and anticancer properties. The antioxidant and prooxidant properties of DPDT are complex and depend on experimental conditions, which may explain the contradictory reports of these properties. In addition, DPDT may exert its effects through different pathways, including distinct ones to those responsible for chemotherapy resistance phenotypes: transcription factors, membrane receptors, adhesion, structural molecules, cell cycle regulatory components, and apoptosis pathways. This review aims to present recent advances in our understanding of the biological effects, therapeutic potential, and safety of DPDT treatment. Moreover, original results demonstrating the cytotoxic effects of DPDT in different mammalian cell lines and systems biology analysis are included, and emerging approaches for possible future applications are inferred.