Antioxidant Activity of Telmisartan–Cu(II) Nanoparticles Connected 2-Pyrimidinamine and Their Evaluation of Cytotoxicity Activities

• Published in: BioMed research international Vol. 2020; no. 2020; pp. 1 - 12
• Main Authors: Ahamed, Nazeer Anis, Alarifi, Saud, Idhayadhulla, Akbar, Surendrakumar, Radhakrishnan, Sathish Kumar, Chidambaram
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Publishing Corporation 2020; Hindawi; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Acids; Antioxidants; Antioxidants - pharmacology; Atomic force microscopy; Benzothiazoles - chemistry; Biotechnology; Catalysis; Catalysts; Cell Death - drug effects; Cell Line, Tumor; Cell lines; Chemical synthesis; Copper; Copper - pharmacology; Cytotoxicity; Derivatives; Doxorubicin; Enzymes; Ethanol; Free Radical Scavengers - chemistry; Free radicals; Green chemistry; Health aspects; Humans; Hypertension; Infrared spectroscopy; Linoleic acid; Lipid Peroxidation - drug effects; Magnetic resonance spectroscopy; Mass spectroscopy; Metal Nanoparticles - chemistry; Metal Nanoparticles - ultrastructure; Methods; Nanoparticles; Nanotechnology; NMR; NMR spectroscopy; Nuclear magnetic resonance; Nuclear magnetic resonance spectroscopy; Particle Size; Peroxidation; Powders; Properties; Pyrimidines - chemical synthesis; Pyrimidines - chemistry; Pyrimidines - pharmacology; Scavenging; Spectrometry, X-Ray Emission; Spectrophotometry, Ultraviolet; Spectroscopy; Spectroscopy, Fourier Transform Infrared; Sulfonic Acids - chemistry; Telmisartan; Telmisartan - chemistry; Telmisartan - pharmacology; Thermogravimetry; Toxicity; Vitamin E; Waviness; X-Ray Diffraction; India
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2020/8872479

Copper nanoparticles (Cu-Nps) are one of the promising materials for the advancement of nanoscience and technology. In this work, we synthesized telmisartan copper nanoparticles and 2-pyrimidinamines via Biginelli reaction using telmisartan copper nanoparticles (Cu-Nps) as a reusable catalyst. The synthesis of 2-pyrimidinamine derivatives (1a-c) was achieved in water and under solvent-free condition (Green chemistry approach). Synthesis of 2-pyrimidinamine with telmisartan copper nanoparticle (Cu-Nps–Pyr) unexpected product was also isolated from synthesis of 2-pyrimidinamine preparation. Antioxidant and cytotoxic activities were carried out both in 2-pyrimidinamine (1a-1c) and 2-pyrimidinamine with telmisartan copper nanoparticles (Cu-Nps–Pyr). The synthesized 2-pyrimidinamine derivatives (1a-c) were characterized from FT-IR, 1H and 13C NMR spectroscopy, mass and elemental analyses. The synthesized telmisartan copper nanoparticles (Cu-Nps) were characterized from UV spectroscopy, XRD, SEM, EDX, AFM (atomic force microscopy), profile, waviness, and roughness analyses. Antioxidant activity was screened based on ABTS⋅+ radical scavenging and linoleic acid peroxidation performance. Cu-Nps–Pyr-1b showed substantial antioxidant (97.2%) activity against ABTS⋅+ assay and 91.2% activity against AAPH assays compared with Trolox. Cytotoxicity was evaluated using HepG2, HeLa, and MCF-7 cell lines, the Cu-Nps–Pyr-1a is high in toxicities (GI50=0.01 μm) against the HeLa cancel cell line compared with doxorubicin. The developed copper NPs with 2-pyrimidinamine (Cu-Nps–Pyr) could provide promising advances as antioxidant activities; this nanocomposition could be considered an anticancer treatment in future investigations.