Carotid Arterial Stiffness and Cardiometabolic Profiles in Women with Fibromyalgia

• Published in: Biomedicines Vol. 9; no. 12; p. 1786
• Main Authors: Kim, Yunkyung, Kim, Geun-Tae, Kang, Jihun
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 28.11.2021; MDPI
• Subjects: Alcohol; arterial stiffness; atherosclerosis; Biomechanics; Blood pressure; Body mass index; cardiometabolic profiles; Carotid artery; Cholesterol; Diabetes; Electronic health records; Fibromyalgia; Glucose; High density lipoprotein; Hypertension; Insulin; Insulin resistance; Laboratories; Lipids; Low density lipoprotein; Medical records; Metabolism; Obesity; Pain; Rheumatology; Risk factors; Sleep; Triglycerides; Ultrasonic imaging; Veins & arteries; United States > US; arterial stiffness; atherosclerosis; cardiometabolic profiles; fibromyalgia
• ISSN: 2227-9059; 2227-9059
• DOI: 10.3390/biomedicines9121786

The present study aimed to evaluate the association between FM and cardiometabolic risk factors and carotid arterial stiffness in FM patients. The cardiometabolic risk profile was defined based on the Adult Treatment Panel III panel. Carotid intimal media thickness (cIMT) and arterial stiffness were assessed using high-resolution ultrasonography. Multivariate logistic analysis was performed to estimate the association between FM and cardiometabolic risk factors. We used a general linear regression to compare the cIMT and carotid beta-index between the participants with and without FM. Pearson's coefficient was calculated to evaluate the potential correlation between cardiometabolic risk profiles, cIMT, and arterial stiffening in FM. FM participants showed a higher risk of central obesity (odds ratio [OR] = 3.21, 95% confidence interval [CI] 1.49, 6.91), high triglyceride (OR = 4.73, 95% CI 2.29, 9.79), and impaired fasting glucose (IFG) (OR = 4.27, 95% CI 2.07, 8.81) compared to the control group. The FM group exhibited higher beta-index values than the control group ( = 0.003). Although IFG and triglyceride glucose index showed a tendency to correlate with the beta-index, statistical significance was not observed. FM was associated with an increased risk of central obesity, high triglyceride levels, and IFG. Furthermore, advanced arterial stiffness of the carotid artery was observed in FM, which might be correlated with insulin resistance.