Systematic Review of Prognostic Role of Blood Cell Ratios in Patients with Gastric Cancer Undergoing Surgery

Various blood cell ratios exist which seem to have an impact on prognosis for resected gastric cancer patients. The aim of this systematic review was to investigate the prognostic role of blood cell ratios in patients with gastric cancer undergoing surgery in a curative attempt. A systematic literat...

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Published inDiagnostics (Basel) Vol. 12; no. 3; p. 593
Main Authors Schiefer, Sabine, Wirsik, Naita Maren, Kalkum, Eva, Seide, Svenja Elisabeth, Nienhüser, Henrik, Müller, Beat, Billeter, Adrian, Büchler, Markus W, Schmidt, Thomas, Probst, Pascal
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 25.02.2022
MDPI
Subjects
Bias
Blood
blood cell ratios
Blood platelets
Cancer therapies
Chemotherapy
confounder
Gastric cancer
Inflammation
Lymphocytes
Medical prognosis
Neutrophils
Patients
prognostic studies
Statistical analysis
Surgery
Systematic Review
Tumors
Asia
confounder
gastric cancer
blood cell ratios
prognostic studies
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Summary:Various blood cell ratios exist which seem to have an impact on prognosis for resected gastric cancer patients. The aim of this systematic review was to investigate the prognostic role of blood cell ratios in patients with gastric cancer undergoing surgery in a curative attempt. A systematic literature search in MEDLINE (via PubMed), CENTRAL, and Web of Science was performed. Information on survival and cut-off values from all studies investigating any blood cell ratio in resected gastric cancer patients were extracted. Prognostic significance and optimal cut-off values were calculated by meta-analyses and a summary of the receiver operating characteristic. From 2831 articles, 65 studies investigated six different blood cell ratios (prognostic nutritional index (PNI), lymphocyte to monocyte ratio (LMR), systemic immune-inflammation index (SII), monocyte to lymphocyte ratio (MLR), neutrophil to lymphocyte ratio (NLR), and platelet to lymphocyte ratio (PLR)). There was a significant association for the PNI and NLR with overall survival and disease-free survival and for LMR and NLR with 5-year survival. The used cut-off values had high heterogeneity. The available literature is flawed by the use of different cut-off values hampering evidence-based patient treatment and counselling. This article provides optimal cut-off values recommendations for future research.
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These authors contributed equally to this work.
ISSN:2075-4418
2075-4418
DOI:10.3390/diagnostics12030593