Long-term outcome characteristics in mesial temporal lobe epilepsy with and without associated cortical dysplasia

• Published in: Epilepsy research Vol. 126; pp. 147 - 156
• Main Authors: Schmeiser, B, Hammen, T, Steinhoff, B.J, Zentner, J, Schulze-Bonhage, A
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.10.2016
• Subjects: Adolescent; Adult; Age Factors; Aged; Child; Child, Preschool; Drug Resistant Epilepsy - complications; Drug Resistant Epilepsy - physiopathology; Drug Resistant Epilepsy - surgery; Epilepsy, Temporal Lobe - complications; Epilepsy, Temporal Lobe - physiopathology; Epilepsy, Temporal Lobe - surgery; Epilepsy, Tonic-Clonic - complications; Epilepsy, Tonic-Clonic - physiopathology; Epilepsy, Tonic-Clonic - surgery; Female; Focal cortical dysplasia; Follow-Up Studies; Functional Laterality; Humans; Kaplan-Meier Estimate; Male; Malformations of Cortical Development - complications; Malformations of Cortical Development - physiopathology; Malformations of Cortical Development - surgery; Middle Aged; Neurology; Predictive factors; Retrospective Studies; Running down phenomenon; Seizure freedom; Seizure outcome; Seizures - complications; Seizures - physiopathology; Seizures - surgery; Surgery; Temporal lobe epilepsy (TLE); Time Factors; Treatment Outcome; Young Adult; seizure freedom; focal cortical dysplasia; seizure outcome; predictive factors; temporal lobe epilepsy (TLE); running down phenomenon; surgery; Seizure outcome; Focal cortical dysplasia; Predictive factors; Surgery; Seizure freedom; Temporal lobe epilepsy (TLE); Running down phenomenon
• ISSN: 0920-1211; 1872-6844
• DOI: 10.1016/j.eplepsyres.2016.07.011

Highlights • Complete seizure freedom achieved in 65.0% at 1 year and in 56.5% at long-term follow-up of ≥5 years after surgery. • Predictors for favorable postoperative seizure outcome differed according to the presence or absence of focal cortical dysplasia in addition to mesiotemporal lesions. • The running down phenomenon was found in 7.2% patients. Yet, its occurrence could not predicted by any of the factors analyzed.