Protective Effects of IL4-589T and RANTES-28G on HIV-1 disease progression in infected Thai females

• Published in: AIDS (London) Vol. 20; no. 2; pp. 189 - 196
• Main Authors: WICHUKCHINDA, Nuanjun, NAKAYAMA, Emi E, ROJANAWIWAT, Archawin, PATHIPVANICH, Panita, AUWANIT, Wattana, VONGSHEREE, Suthon, ARIYOSHI, Koya, SAWANPANYALERT, Pathom, SHIODA, Tatsuo
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 09.01.2006
• Subjects: AIDS/HIV; Biological and medical sciences; CD4 Lymphocyte Count; Chemokine CCL5 - genetics; Disease Progression; Epidemiologic Methods; Female; Gene Frequency; Genetic Predisposition to Disease; Genotype; HIV Infections - genetics; HIV Infections - immunology; HIV Infections - virology; HIV Long-Term Survivors; HIV-1 - isolation & purification; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunopathology; Infectious diseases; Interleukin-4 - genetics; Male; Medical sciences; Polymorphism, Genetic; Prognosis; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; Viral Load; Thailand; Asia; Immunopathology; HIV disease progression; Prognosis; IL4-589T; RANTES; AIDS; RANTES promoter polymorphisms; Thailand; Immune deficiency; Survival; Infection; Prevention; Microbiological investigation; Immunological investigation; Viral disease; T-Lymphocyte; Evolution; Female; Viral load; CD4 cells; Polymorphism
• ISSN: 0269-9370; 1473-5571
• DOI: 10.1097/01.aids.0000199830.64735.6f

To evaluate the effect of polymorphisms in interleukin-4 (IL4) and RANTES promoters on disease progression in HIV-1 infected Thais. Antiretroviral (ARV) drug-free HIV-1 infected females from the prospective cohort. A total of 246 DNA samples were genotyped for IL4 and RANTES promoter polymorphisms by PCR-RFLP. Associations of genotype with HIV-1 disease progression were assessed with respect to baseline clinical data including plasma HIV-1 load, CD4 cell counts, and proportion of symptomatic/AIDS, and survival status during 3 years of follow-up. Patients with homozygous IL4-589T allele showed a significantly lower HIV-1 viral load (P = 0.005) and a higher CD4 cell count (P = 0.003) than the other patients with heterozygous IL4-589C/T or homozygous IL4-589C allele. Kaplan-Meier analysis demonstrated an apparent but insignificant trend towards better survival in homozygous IL4-589T patients. On the other hand, patients with RANTES-28G allele showed a significantly better survival while those with RANTES In1.1C allele without RANTES-28G showed a significantly poorer survival compared with those who did not possess either RANTES In1.1C or RANTES-28G (P = 0.02), although those polymorphisms only weakly associated with baseline viral load and CD4 cell counts. Our results implicate the significant protective effect of IL4-589T and RANTES-28G on HIV disease progression in Thais. In contrast, RANTES In1.1C without RANTES-28G had an accelerating effect on HIV disease progression.