Sex Differences in Brain Regions Modulating Pain Among Older Adults: A Cross-Sectional Resting State Functional Connectivity Study

• Published in: Pain medicine (Malden, Mass.) Vol. 19; no. 9; pp. 1737 - 1747
• Main Authors: Monroe, Todd B, Fillingim, Roger B, Bruehl, Stephen P, Rogers, Baxter P, Dietrich, Mary S, Gore, John C, Atalla, Sebastian W, Cowan, Ronald L
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.09.2018
• Subjects: Aged; Amygdala; Brain; Brain - physiopathology; Comparative analysis; Cortex (cingulate); Cortex (somatosensory); Cross-Sectional Studies; Diagnostic imaging; Female; Females; Gender differences; Humans; Magnetic Resonance Imaging; Male; Males; Middle Aged; Neural networks; Neural Pathways - physiopathology; Neuroimaging; Neurophysiology; Older people; Pain; PAIN & AGING SECTION; Pain - physiopathology; Pain management; Pain Threshold - physiology; Periaqueductal gray area; Psychophysics; Rest; Sex Characteristics; Sex differences; Sex differences (Psychology); Substantia grisea; Temperature perception; Thermal stimuli; Neuroimaging; Experimental Thermal Pain; Resting State Functional Connectivity; Descending Modulation; Perception; Sex Differences
• ISSN: 1526-2375; 1526-4637
• DOI: 10.1093/pm/pnx084

Abstract Objective A long-standing hypothesis is that when compared with males, females may be at increased risk of experiencing greater pain sensitivity and unpleasantness. The purpose of this study was to examine sex differences in pain psychophysics and resting state functional connectivity (RSFC) in core pain regions in an age- and sex-matched sample of healthy older adults. Design Between groups, cross-sectional. Setting Vanderbilt University and Medical Center. Subjects The sample in the analyses reported here consisted of 19 cognitively intact males matched with 19 cognitively intact females of similar ages (median ages: females = 70 years, males = 68 years). Methods Psychophysical assessment of experimental thermal pain and RSFC. Results There were no significant differences in perceptual thresholds or unpleasantness ratings in response to thermal stimuli. Older males showed greater RSFC between the affective and sensory networks and between affective and descending modulatory networks. Conversely, older females showed greater RSFC between the descending modulatory network and both sensory and affective networks. The strongest evidence for sex differences emerged in the associations of thermal pain with RSFC between the anterior cingulate cortex (ACC) and amygdala and between the ACC and periaqueductal gray matter in older females relative to older males. Conclusions We found no differences in pain sensitivity or pain affect between older males and older females. Additionally, we found that older females exhibited a greater association between thermal pain sensitivity and RSFC signal between regions typically associated with pain affect and the descending modulatory system. One interpretation of these findings is that older females may better engage the descending pain modulatory system. This better engagement possibly translates into older females having similar perceptual thresholds for temperature sensitivity and unpleasantness associated with mild and moderate pain. These findings contrast with studies demonstrating that younger females find thermal pain more sensitive and more unpleasant.