The Role of Pelvic Exenteration in Cervical Cancer: A Review of the Literature

• Published in: Cancers Vol. 16; no. 4; p. 817
• Main Authors: Ubinha, Ana Carla Franco, Pedrão, Priscila Grecca, Tadini, Aline Cássia, Schmidt, Ronaldo Luis, Santos, Marcelo Henrique Dos, Andrade, Carlos Eduardo Mattos da Cunha, Longatto Filho, Adhemar, Reis, Ricardo Dos
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.02.2024
• Subjects: Age; Bladder; Body mass index; Cancer therapies; Care and treatment; Cervical cancer; Chemoradiotherapy; Development and progression; Diseases; extended pelvic resection; Literature reviews; Medical prognosis; Mortality; Obesity; Patients; pelvic exenteration; Pelvis; recurrent cervical cancer; Relapse; Survival; Toxicity; Tumors; Vagina; Canada; extended pelvic resection; recurrent cervical cancer; pelvic exenteration; cervical cancer
• ISSN: 2072-6694; 2072-6694
• DOI: 10.3390/cancers16040817

Pelvic exenteration represents a radical procedure aimed at achieving complete tumor resection with negative margins. Although it is the only therapeutic option for some cases of advanced tumors, it is associated with several perioperative complications. We believe that careful patient selection is related to better oncologic outcomes and lower complication rates. The objectives of this review are to identify the most current indications for this intervention, suggest criteria for case selection, evaluate recommendations for perioperative care, and review oncologic outcomes and potential associated complications. To this end, an analysis of English language articles in PubMed was performed, searching for topics such as the indication for pelvic exenteration for recurrent gynecologic neoplasms selection of oncologic cases, the impact of tumor size and extent on oncologic outcomes, preoperative and postoperative surgical management, surgical complications, and outcomes of overall survival and recurrence-free survival.