Synthesis of injectable and cohesive nano hydroxyapatite scaffolds

• Published in: Journal of materials science. Materials in medicine Vol. 23; no. 4; pp. 913 - 919
• Main Authors: Varma, Nitin Pratap, Garai, Subhadra, Sinha, Arvind
• Format: Journal Article
• Language: English
• Published: Boston Springer US 01.04.2012; Springer; Springer Nature B.V
• Subjects: Ball milling; Biological and medical sciences; Biomaterials; Biomedical Engineering and Bioengineering; Biomedical materials; Biomimetics; Blood; Ceramics; Chemistry and Materials Science; Composites; Durapatite - chemistry; Glass; Humans; Hydroxyapatite; Materials Science; Medical sciences; Microscopy, Electron, Scanning; Microscopy, Electron, Transmission; Nanocomposites; Nanomaterials; Nanoparticles; Nanostructure; Nanotechnology; Natural Materials; Pastes; Polymer Sciences; Regenerative Medicine/Tissue Engineering; Stability; Surfaces and Interfaces; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Technology. Biomaterials. Equipments; Thin Films; X-Ray Diffraction; Biphasic Calcium Phosphate; DCPD; Amorphous Calcium Phosphate; Dicalcium Phosphate; DCPA; Injectable form; Hydroxyapatite; Synthesis; Scaffold; Preparation; Biomedical engineering
• ISSN: 0957-4530; 1573-4838
• DOI: 10.1007/s10856-012-4579-5

Biomimetically synthesized nanosized hydroxyapatite particles have been converted into an injectable paste using a neutral phosphate buffer. Synthesized system manifested a self setting behavior at 37°C in 20 min and revealed a macroporous self assembled microstructure. Stability of the injectable hydroxyapatite has been confirmed in aqueous medium as well as in human blood. Effect of ball milling was also studied on the stability of the system.