Clinical significance of histone deacetylases 1, 2, 3, and 7: HDAC2 is an independent predictor of survival in HCC

• Published in: Virchows Archiv : an international journal of pathology Vol. 459; no. 2; pp. 129 - 139
• Main Authors: Quint, Karl, Agaimy, Abbas, Di Fazio, Pietro, Montalbano, Roberta, Steindorf, Claudia, Jung, Rudolf, Hellerbrand, Claus, Hartmann, Arndt, Sitter, Helmut, Neureiter, Daniel, Ocker, Matthias
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer-Verlag 01.08.2011; Springer; Springer Nature B.V
• Subjects: Biological and medical sciences; Biomarkers, Tumor - analysis; Biomarkers, Tumor - metabolism; Carcinoma, Hepatocellular - enzymology; Carcinoma, Hepatocellular - mortality; Carcinoma, Hepatocellular - pathology; Chromatin remodeling; Female; Gastroenterology. Liver. Pancreas. Abdomen; Histone Deacetylase 2 - biosynthesis; Histone Deacetylases - biosynthesis; Humans; Immunohistochemistry; Investigative techniques, diagnostic techniques (general aspects); Ki-67 Antigen - biosynthesis; Liver Neoplasms - enzymology; Liver Neoplasms - mortality; Liver Neoplasms - pathology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; Medical sciences; Medicine; Medicine & Public Health; Middle Aged; Neoplasm Staging; Original Article; Pathology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Survival; Tissue Array Analysis; Tissues; Tumors; Expression analysis; Hepatocellular carcinoma; Tissue microarray; Histone deacetylases; Overall survival; Correlation analysis; Histone deacetylase; Prediction; Hepatic disease; Malignant tumor; Survival; Liver cancer; Anatomic pathology; Tissue microarrays; Digestive diseases; Predictive factor; Cancer
• ISSN: 0945-6317; 1432-2307
• DOI: 10.1007/s00428-011-1103-0

Histone deacetylases (HDAC) are responsible for the transcriptional control of genes through chromatin remodeling and control tumor suppressor genes. In several tumors, their expression has been linked to clinicopathological factors and patient survival. This study investigates HDACs 1, 2, 3, and 7 expressions in hepatocellular carcinoma (HCC) and their correlation with clinical data and patient survival. Tissue microarrays of 170 surgically resected primary HCCs and adjacent uninvolved tissue were evaluated immunohistochemically for the expression of HDACs 1, 2, 3, 7, and Ki-67 and were analyzed with respect to clinicopathological data and patient survival. HDACs 1, 2, 3, and Ki-67 were expressed significantly higher in cancer cells compared to normal tissue (HDAC1: p  = 0.034, HDACs 2 and 3 and Ki-67: p  < 0.001), while HDAC7 expression did not differ between HCC and non-cancerous liver tissue. In tumor tissue HDACs 1–3 expression levels showed high concordance with each other, Ki-67 and tumor grade ( p  < 0.001). High HDAC2 expression was associated with poor survival in low-grade and early-stage tumors ( p  < 0.05). The expression of the HDACs 1, 2, and 3 (but not HDAC7) isoenzymes correlates with clinicopathological factors, and HDAC2 expression has an impact on patient survival.