Homeostatic effect of p-chloro-diphenyl diselenide on glucose metabolism and mitochondrial function alterations induced by monosodium glutamate administration to rats

• Published in: Amino acids Vol. 48; no. 1; pp. 137 - 148
• Main Authors: Quines, Caroline B, Rosa, Suzan G, Chagas, Pietro M, da Rocha, Juliana T, Dobrachinski, Fernando, Carvalho, Nélson R, Soares, Félix A, da Luz, Sônia C. Almeida, Nogueira, Cristina W
• Format: Journal Article
• Language: English
• Published: Vienna Springer Vienna 01.01.2016; Springer Nature B.V
• Subjects: adenosine diphosphate; adenosine monophosphate; adenosine triphosphate; Alterations; Analytical Chemistry; Animals; Biochemical Engineering; Biochemistry; Biomedical and Life Sciences; blood glucose; cholesterol; Cholesterol - metabolism; citrate (si)-synthase; Citrates; Female; Glucose; Glucose - metabolism; glucose-6-phosphatase; Glutamates; glycemic effect; glycogen; growth performance; growth retardation; hexokinase; Homeostasis - drug effects; Humans; Life Sciences; liver; Liver - drug effects; Liver - metabolism; Male; Mathematical models; metabolic syndrome; Metabolism; Mitochondria - drug effects; Mitochondria - metabolism; monosodium glutamate; Neurobiology; obesity; Obesity - drug therapy; Obesity - etiology; Obesity - metabolism; Organoselenium Compounds - administration & dosage; Original Article; Proteomics; public health; Rats; Rats, Wistar; selenium; Selenium compounds; Sodium Glutamate - adverse effects; Sodium Glutamate - metabolism; triacylglycerols; Triglycerides - metabolism; tyrosine transaminase; Rats; Obesity; Monosodium glutamate; Metabolic syndrome; Organoselenium
• ISSN: 0939-4451; 1438-2199
• DOI: 10.1007/s00726-015-2073-3

The metabolic syndrome is a group of metabolic alterations considered a worldwide public health problem. Organic selenium compounds have been reported to have many different pharmacological actions, such as anti-hypercholesterolemic and anti-hyperglycemic. The aim of this study was to evaluate the effect of p-chloro-diphenyl diselenide (p-ClPhSe)₂, an organic selenium compound, in a model of obesity induced by monosodium glutamate (MSG) administration in rats. The rats were treated during the first ten postnatal days with MSG and received (p-ClPhSe)₂ (10 mg/kg, intragastrically) from 45th to 51th postnatal day. Glucose, lipid and lactate levels were determined in plasma of rats. Glycogen levels and activities of tyrosine aminotransferase, hexokinase, citrate synthase and glucose-6-phosphatase (G-6-Pase) were determined in livers of rats. Renal G-6-Pase activity was also determined. The purine content [Adenosine triphosphate (ATP), adenosine diphosphate (ADP) and adenosine monophosphate] and mitochondrial functionality in the liver were also investigated. p-(ClPhSe)₂ did not alter the reduction in growth performance and in the body weight caused by MSG but reduced epididymal fat deposition of rats. p-(ClPhSe)₂ restored glycemia, triglycerides, cholesterol and lactate levels as well as the glucose metabolism altered in rats treated with MSG. p-(ClPhSe)₂ restored hepatic mitochondrial dysfunction and the decrease in citrate synthase activity and ATP and ADP levels caused by MSG in rats. In summary, (p-ClPhSe)₂ had homeostatic effects on glucose metabolism and mitochondrial function alterations induced by MSG administration to rats.