Influence of Positive End-Expiratory Pressure Titration on the Effects of Pronation in Acute Respiratory Distress Syndrome: A Comprehensive Experimental Study
Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested...
Saved in:
Published in | Frontiers in physiology Vol. 11; p. 179 |
---|---|
Main Authors | , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Switzerland
Frontiers Media S.A
12.03.2020
|
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Prone position can reduce mortality in acute respiratory distress syndrome (ARDS), but several studies found variable effects on oxygenation and lung mechanics. It is unclear whether different positive end-expiratory pressure (PEEP) titration techniques modify the effect of prone position. We tested, in an animal model of ARDS, if the PEEP titration method may influence the effect of prone position on oxygenation and lung protection. In a crossover study in 10 piglets with a two-hit injury ARDS model, we set the "best PEEP" according to the ARDS Network low-PEEP table (BP
) or targeting the lowest transpulmonary driving pressure (BP
). We measured gas exchange, lung mechanics, aeration, ventilation, and perfusion with computed tomography (CT) and electrical impedance tomography in each position with both PEEP titration techniques. The primary endpoint was the PaO
/FiO
ratio. Secondary outcomes were lung mechanics, regional distribution of ventilation, regional distribution of perfusion, and homogeneity of strain derived by CT scan. The PaO
/FiO
ratio increased in prone position when PEEP was set with BP
[difference 54 (19-106) mmHg,
= 0.04] but not with BP
[difference 17 (-24 to 68) mmHg,
= 0.99]. The transpulmonary driving pressure significantly decreased during prone position with both BP
[difference -0.9 (-1.5 to -0.9) cmH
O,
= 0.009] and BP
[difference -0.55 (-1.6 to -0.4) cmH
O,
= 0.04]. Pronation homogenized lung regional strain and ventilation and redistributed the ventilation/perfusion ratio along the sternal-to-vertebral gradient. The PEEP titration technique influences the oxygenation response to prone position. However, the lung-protective effects of prone position could be independent of the PEEP titration strategy. |
---|---|
Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 These authors have contributed equally to this work This article was submitted to Respiratory Physiology, a section of the journal Frontiers in Physiology Reviewed by: Ling Liu, Zhongda Hospital Southeast University, China; Carmen Silvia Valente Barbas, University of São Paulo, Brazil; Yi Yang, Zhongda Hospital Southeast University, China Edited by: Walter Araujo Zin, Federal University of Rio de Janeiro, Brazil |
ISSN: | 1664-042X 1664-042X |
DOI: | 10.3389/fphys.2020.00179 |