Molecular properties of Cinchona alkaloids: a theoretical approach

• Published in: Journal of pharmaceutical sciences Vol. 81; no. 2; p. 122
• Main Authors: Oleksyn, B J, Suszko-Purzycka, A, Dive, G, Lamotte-Brasseur, J
• Format: Journal Article
• Language: English
• Published: United States 01.02.1992
• Subjects: Cinchona Alkaloids - chemistry; Molecular Conformation
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600810204

In the present work, the conformation analysis, electrostatic potential calculations, and proton affinity evaluation are carried out for Cinchona alkaloids using theoretical molecular mechanics and quantum mechanical methods. The most probable conformation of the active erythro isomers at the receptor site seems to be that which enables the molecule to form intermolecular hydrogen bonds. In epiquinidine, the mutual orientation of O(12) and N(1) atoms favors intra- rather than intermolecular bonding, and this might be responsible for its inactivity. Comparison of the shape and size of the negative electrostatic potential areas provides a tentative explanation for the interaction of different erythro diastereoisomers with the same putative receptor, as well as for lack of such interaction in epiquinidine. The protonation energies calculated for cinchonidine and cinchonine confirm the higher basicity of the aliphatic N(1) as compared with that of the aromatic N(13) atom.