Cardiac output during exercise: A comparison of four methods

• Published in: Scandinavian journal of medicine & science in sports Vol. 25; no. 1; pp. e20 - e27
• Main Authors: Siebenmann, C., Rasmussen, P., Sørensen, H., Zaar, M., Hvidtfeldt, M., Pichon, A., Secher, N. H., Lundby, C.
• Format: Journal Article
• Language: English
• Published: Denmark Blackwell Publishing Ltd 01.02.2015
• Subjects: Adult; ARTERIAL-PRESSURE; BLOOD-FLOW; Cardiac Catheterization - methods; Cardiac Output - physiology; Cardiography, Impedance - methods; Cardiovascular system; EXERCISE; Exercise - physiology; Exercise Test - methods; Fysiologi och anatomi; GAS REBREATHING TECHNIQUE; HEART-FAILURE PATIENTS; Humans; hypoxia; Hypoxia - physiopathology; IMPEDANCE CARDIOGRAPH DEVICE; impedance cardiography; Inert gas rebreathing; LEG EXERCISE; Male; MAXIMAL AEROBIC; maximal oxygen; maximal oxygen uptake; Nitrous Oxide - analysis; NONINVASIVE MEASUREMENT; Oxygen Consumption - physiology; Physiology and Anatomy; pulse contour analysis; Pulse Wave Analysis - methods; RECIRCULATION TIME; Sport Sciences; Sports medicine; STROKE VOLUME; Young Adult; hypoxia; pulse contour analysis; impedance cardiography; Inert gas rebreathing; maximal oxygen uptake
• ISSN: 0905-7188; 1600-0838; 1600-0838
• DOI: 10.1111/sms.12201

Several techniques assessing cardiac output (Q) during exercise are available. The extent to which the measurements obtained from each respective technique compares to one another, however, is unclear. We quantified Q simultaneously using four methods: the Fick method with blood obtained from the right atrium (QFick‐M), Innocor (inert gas rebreathing; QInn), Physioflow (impedance cardiography; QPhys), and Nexfin (pulse contour analysis; QPulse) in 12 male subjects during incremental cycling exercise to exhaustion in normoxia and hypoxia (FiO2 = 12%). While all four methods reported a progressive increase in Q with exercise intensity, the slopes of the Q/oxygen uptake (VO2) relationship differed by up to 50% between methods in both normoxia [4.9 ± 0.3, 3.9 ± 0.2, 6.0 ± 0.4, 4.8 ± 0.2 L/min per L/min (mean ± SE) for QFick‐M, QInn, QPhys and QPulse, respectively; P = 0.001] and hypoxia (7.2 ± 0.7, 4.9 ± 0.5, 6.4 ± 0.8 and 5.1 ± 0.4 L/min per L/min; P = 0.04). In hypoxia, the increase in the Q/VO2 slope was not detected by Nexfin. In normoxia, Q increases by 5–6 L/min per L/min increase in VO2, which is within the 95% confidence interval of the Q/VO2 slopes determined by the modified Fick method, Physioflow, and Nexfin apparatus while Innocor provided a lower value, potentially reflecting recirculation of the test gas into the pulmonary circulation. Thus, determination of Q during exercise depends significantly on the applied method.