High CRP-albumin ratio predicts poor prognosis in transplant ineligible elderly patients with newly diagnosed acute myeloid leukemia

• Published in: Scientific reports Vol. 12; no. 1; p. 8885
• Main Authors: Senjo, Hajime, Onozawa, Masahiro, Hidaka, Daisuke, Yokoyama, Shota, Yamamoto, Satoshi, Tsutsumi, Yutaka, Haseyama, Yoshihito, Nagashima, Takahiro, Mori, Akio, Ota, Shuichi, Sakai, Hajime, Ishihara, Toshimichi, Miyagishima, Takuto, Kakinoki, Yasutaka, Kurosawa, Mitsutoshi, Kobayashi, Hajime, Iwasaki, Hiroshi, Hashimoto, Daigo, Kondo, Takeshi, Teshima, Takanori
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 25.05.2022; Nature Publishing Group; Nature Portfolio
• Subjects: 631/67/1990/283/1897; 692/53/2422; Acute myeloid leukemia; Albumin; Humanities and Social Sciences; Inflammation; Leukemia; Medical prognosis; multidisciplinary; Multivariate analysis; Nutritional status; Prognosis; Science; Science (multidisciplinary); Solid tumors; Stem cell transplantation
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-022-12813-1

Acute myeloid leukemia (AML) patients older than 65 years have a poor prognosis. Recently, CAR (C-reactive-protein/albumin ratio) has been actively reported as a prognostic index reflecting the nutritional and inflammatory status of elderly patients with solid tumors, but the usefulness of this index as a prognostic indicator in transplant-ineligible elderly AML patients has not been investigated. We studied genetic alterations and CARs in 188 newly diagnosed AML patients aged 65 years or older who were treated in a multicenter setting and had treated without HSCT. Both NCCN 2017 risk group, reflecting the genetic component of the tumor, and CAR, reflecting the inflammatory and nutritional status of the patient, successfully stratified the overall survival (OS) of the patients (2-year OS; CAR low vs high, 42.3% vs 17.8%, P  < 0.001). Furthermore, in multivariate analysis, NCCN 2017 poor group and high CAR were extracted as independent poor prognostic factors predicting 2-year OS in the current study. We found, for the first time, that CAR at diagnosis predicted the prognosis of elderly patients with newly diagnosed AML treated without HSCT.