Effects of supra-physiological changes in human ovarian hormone levels on maximum force production of the first dorsal interosseus muscle

• Published in: Experimental physiology Vol. 90; no. 2; pp. 215 - 223
• Main Authors: Elliott, Kirsty Jayne, Cable, Nigel Timothy, Reilly, Thomas, Sefton, Victoria, Kingsland, Charles, Diver, Michael
• Format: Journal Article
• Language: English
• Published: 9600 Garsington Road , Oxford , OX4 2DQ , UK The Physiological Society 01.03.2005; Blackwell Science Ltd; John Wiley & Sons, Inc
• Subjects: Adult; Cross-Sectional Studies; Female; Fertilization in Vitro; Fingers - physiology; Gonadal Steroid Hormones - blood; Humans; Isometric Contraction - physiology; Muscle, Skeletal - physiology; Ovary - metabolism; Physical Exertion - physiology; Pregnancy - blood; Pregnancy - physiology
• ISSN: 0958-0670; 1469-445X
• DOI: 10.1113/expphysiol.2004.028258

The purpose of this study was to investigate the effects of supra-physiological changes in ovarian hormone levels on maximum force production in two conditions, one physiological (pregnancy) and one pseudo-physiological ( in vitro fertilization (IVF) treatment). Forty IVF patients were tested at four distinct stages of treatment and 35 women were tested during each trimester of pregnancy and following parturition. Maximum voluntary isometric force per unit cross-sectional area of the first dorsal interosseus muscle was measured. Plasma concentrations of total and bioavailable oestradiol and testosterone were measured, in addition to the total concentrations of progesterone and human chorionic gonadotropin. Despite significant changes in the concentrations of total progesterone, 17β-oestradiol, bioavailable oestradiol and testosterone between phases, strength did not change significantly throughout IVF treatment (1.30 ± 0.29, 1.16 ± 0.38, 1.20 ± 0.29 and 1.26 ± 0.34 N mm −2 , respectively, in the 4 phases of IVF treatment). Force production was significantly higher during the second trimester of pregnancy than following childbirth (1.33 ± 0.20 N mm −2 at week 12 of pregnancy, 1.51 ± 0.42 N mm −2 at week 20, 1.15 ± 0.26 N mm −2 at week 36 and 0.94 ± 0.31 N mm −2 at week 6 postnatal) but was not significantly correlated with any of the hormones measured. These data suggest that extreme changes in the concentrations of reproductive hormones do not affect the maximum force-generating capacity of young women.