Mean yield pressure from the in-die Heckel analysis is a reliable plasticity parameter

Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiti...

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Bibliographic Details
Published inInternational journal of pharmaceutics: X Vol. 3; p. 100094
Main Authors Vreeman, Gerrit, Sun, Changquan Calvin
Format Journal Article
LanguageEnglish
Published Elsevier B.V 01.12.2021
Elsevier
Subjects
Compaction
Heckel analysis
In-die
Plasticity
Powder
Research Paper
Compaction
In-die
Heckel analysis
Powder
Plasticity
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Summary:Despite the ability to characterize the plasticity of powders in a material-sparing and expedited manner, the in-die Heckel analysis has been widely criticized for its sensitivity to several factors, such as particle elastic deformation, tooling size, lubrication, and speed. Using materials exhibiting a wide range of mechanical properties, we show that the in-die Py correlates strongly with three established plasticity parameters obtained from the out-of-die Heckel analysis, Kuentz-Leuenberger analysis, and macroindentation. Thus, the in-die Py is a reliable parameter for quantifying powder plasticity in a material-sparing and expedited manner. [Display omitted]
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ISSN:2590-1567
2590-1567
DOI:10.1016/j.ijpx.2021.100094