Induction of Systemic Antifimbria and Antitoxin Antibody Responses in Egyptian Children and Adults by an Oral, Killed Enterotoxigenic Escherichia coli plus Cholera Toxin B Subunit Vaccine

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Published inInfection and Immunity Vol. 69; no. 5; pp. 2853 - 2857
Main Authors Hall, Eric R., Wierzba, Thomas F., Åhrén, Christina, Rao, Malla R., Bassily, Samir, Francis, Wagdy, Girgis, Fouad Y., Safwat, Mohamed, Lee, Young J., Svennerholm, Ann-Mari, Clemens, John D., Savarino, Stephen J.
Format Journal Article
LanguageEnglish
Published Washington, DC American Society for Microbiology 01.05.2001
Subjects
Administration, Oral
Adult
Antibodies, Bacterial - blood
Bacterial Proteins - immunology
Bacterial Vaccines - immunology
Bacteriology
Biological and medical sciences
Child
Child, Preschool
Cholera Toxin - immunology
colonization factor
colonization factors
Egypt
Escherichia coli
Escherichia coli - immunology
Fimbriae Proteins
Fundamental and applied biological sciences. Psychology
Humans
Immunoglobulin A - blood
Immunoglobulin G - blood
Microbial Immunity and Vaccines
Microbiology
Middle Aged
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies
Vaccines, Synthetic - immunology
Human
Immunization
Antibody
Induction
Escherichia coli
Vibrio cholerae
Systemic
Vaccine
Subunit
Blood
Infection
Toxin
Bacteriosis
Bacteria
Vibrionaceae
Cholera
Cell
Dose
Child
Humoral immunity
Enterobacteriaceae
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Corresponding author. Present address: Enteric Diseases Department, Naval Medical Research Center, 503 Robert Grant Ave., Silver Spring, MD 20910. Phone: (301) 319-7663. Fax: (301) 319-7679. E-mail: savarinos@nmrc.navy.mil.
Present address: International Vaccine Institute, Seoul, Korea.
Member of the Pediatric Research on Immunization against Diarrhea in Egypt (PRIDE) Study Group, which includes Robert Frenck, Remon Abu Elyazeed, Nemat El Ghorab, Leonard F. Peruski, Jr., Karim Kamal, Ibrahim Abdel-Messih, Hanan El Mohamady, and Hind Shaheen, U.S. Naval Medical Research Unit No. 3, Cairo, Egypt; Abdollah Naficy and Patricia Moyer, National Institute of Child Health and Human Development, Bethesda, Md.; Anwar A. Latif, Abdel Fattah Ahmed, Abdel Kader Ahmed, Mokhtar A. Aty, and Mohamed I. Ibrahim, Ministry of Health and Population, Qalyubia Governorate, Egypt; and Marianne Jertborn, University of Göteborg, Sweden.
Present address: Enteric Diseases Department, Naval Medical Research Center, Silver Spring, Maryland.
ISSN:0019-9567
1098-5522
DOI:10.1128/IAI.69.5.2853-2857.2001