Physiology and pathophysiology of the RANKL/RANK system

The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was en...

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Bibliographic Details
Published inBiological chemistry Vol. 391; no. 12; pp. 1365 - 1370
Main Authors Hanada, Reiko, Hanada, Toshikatsu, Penninger, Josef M.
Format Journal Article
LanguageEnglish
Published Germany Walter de Gruyter 01.12.2010
Subjects
Animals
Body Temperature
bone physiology
Bone Remodeling
Central Nervous System - physiopathology
central nervous systems
Female
fever
Fever - physiopathology
Humans
immunology
Models, Biological
Osteoclasts - metabolism
osteoporosis
Prostaglandins - metabolism
RANK Ligand - physiology
Receptor Activator of Nuclear Factor-kappa B - physiology
Signal Transduction
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Summary:The TNF family molecule RANKL and its receptor RANK are key regulators of bone remodeling, lymph node formation, and mammary gland development during pregnancy. RANKL and RANK are also expressed in the central nervous systems (CNS). However, the functional relevance of RANKL/RANK in the brain was entirely unknown. Recently, our group reported that the RANKL/RANK signaling pathway has an essential role in the central regulation of body temperature via the prostaglandin axis. This review discusses novel aspects of the RANKL/RANK system as key regulators of fever and female basal body temperature in the CNS.
Bibliography:ark:/67375/QT4-7G12B6R1-4
ArticleID:bc.2010.149
istex:86B875DAFB07A06F971289E2329096E57B5D6008
bc.2010.149.pdf
ObjectType-Article-2
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ObjectType-Review-1
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ISSN:1431-6730
1437-4315
DOI:10.1515/bc.2010.149