Literature review and suggested protocol for prevention and treatment of corneal graft rejection

Effective prophylaxis and treatment of corneal graft rejection are essential to improve outcomes in corneal transplantation. To date, there has been no standardized protocol published that outlines the optimal prophylactic and therapeutic approaches and, furthermore, the published controlled trials...

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Bibliographic Details
Published inEye (London) Vol. 34; no. 3; pp. 442 - 450
Main Authors Azevedo Magalhaes, Otavio, Shalaby Bardan, Ahmed, Zarei-Ghanavati, Mehran, Liu, Christopher
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.03.2020
Nature Publishing Group
Subjects
631/250/1854
692/700/565/251/1574
Cornea
Corneal transplantation
Graft rejection
Laboratory Medicine
Literature reviews
Medicine
Medicine & Public Health
Ophthalmology
Pharmaceutical Sciences/Technology
Prophylaxis
Review
Review Article
Surgery
Surgical Oncology
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Summary:Effective prophylaxis and treatment of corneal graft rejection are essential to improve outcomes in corneal transplantation. To date, there has been no standardized protocol published that outlines the optimal prophylactic and therapeutic approaches and, furthermore, the published controlled trials on this subject are limited. Likewise, no study has addressed how the level of antigen exposure varies between different types of keratoplasties. The aim of this paper is to provide a simple evidence-based protocol for the prevention and treatment of corneal graft rejection.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0950-222X
1476-5454
DOI:10.1038/s41433-019-0517-9