Model-based assessment of dynamic arterial blood volume flow from ultrasound measurements

• Published in: Medical & biological engineering & computing Vol. 47; no. 6; pp. 641 - 648
• Main Authors: Leguy, C. A. D, Bosboom, E. M. H, Hoeks, A. P. G, van de Vosse, F. N
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.06.2009; Springer-Verlag; Springer Nature B.V
• Subjects: Adult; Biomedical and Life Sciences; Biomedical Engineering and Bioengineering; Biomedicine; Blood; Blood Flow Velocity - physiology; Blood vessels; Blood Volume - physiology; Brachial Artery - diagnostic imaging; Brachial Artery - physiology; Computer Applications; Human Physiology; Humans; Imaging; Investigations; Male; Measurement techniques; Measuring instruments; Medical imaging; Models, Cardiovascular; Original Article; Pulsatile Flow - physiology; Radiology; Registration; Risk assessment; Studies; Ultrasonic imaging; Ultrasonography, Doppler - methods; Veins & arteries; Velocity; Young Adult; Rise time; Poiseuille profile; Blood volume flow; Ultrasound; Womersley profile; Brachial artery
• ISSN: 0140-0118; 1741-0444
• DOI: 10.1007/s11517-009-0473-9

To assess in clinical practice arterial blood volume flow (BVF) from ultrasound measurements, the assumption is commonly made that the velocity profile can be approximated by a quasi-static Poiseuille model. However, pulsatile flow behaviour is more accurately described by a Womersley model. No clinical studies have addressed the consequences on the estimated dynamics of the BVF when Poiseuille rather than Womersley models are used. The aim of this study is to determine the influence of assumed Poiseuille profile instead of Womersley profile on the estimation and intrasubject variability of dynamical parameters of the BVF. For this purpose, a low number of volunteers sufficed. Brachial artery centerline velocity waveform and vessel diameter were measured with ultrasound within a small group of six volunteers. Within subjects, the intra- and inter-registration variability of BVF parameters estimates did not significantly differ. Poiseuille profiles compared to Womersley underestimates the maximum BVF by 19%, the maximum retrograde volume flow by 32% and the rise time by 18%. It can be concluded that when estimating in a straight vessel the dynamic properties of the BVF, Womersley profiles should preferably be chosen.