A DNA damage-induced, SOS-independent checkpoint regulates cell division in Caulobacter crescentus

• Published in: PLoS biology Vol. 12; no. 10; p. e1001977
• Main Authors: Modell, Joshua W, Kambara, Tracy K, Perchuk, Barrett S, Laub, Michael T
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 01.10.2014; Public Library of Science (PLoS)
• Subjects: Bacteria; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biology and Life Sciences; Caulobacter crescentus - physiology; Cell cycle; Cell Cycle Checkpoints; Cell Division; Chromosomes; Deoxyribonucleic acid; DNA; DNA Damage; Genomes; Membrane Proteins - genetics; Membrane Proteins - metabolism; Microscopy; Mutation, Missense; Plasmids; Proteins; Studies; Suppression, Genetic; Transcription factors; Transcription Factors - metabolism

Cells must coordinate DNA replication with cell division, especially during episodes of DNA damage. The paradigm for cell division control following DNA damage in bacteria involves the SOS response where cleavage of the transcriptional repressor LexA induces a division inhibitor. However, in Cauloba...