Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

The view of DNA packaging into chromatin as a mere obstacle to DNA repair is evolving. In this review, we focus on histone variants and heterochromatin proteins as chromatin components involved in distinct levels of chromatin organization to integrate them as real players in the DNA damage response...

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Bibliographic Details
Published inMolecular cell Vol. 46; no. 6; pp. 722 - 734
Main Authors Soria, Gaston, Polo, Sophie E., Almouzni, Geneviève
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 29.06.2012
Subjects
Animals
Chromatin - metabolism
DNA
DNA - metabolism
DNA Damage
DNA packaging
DNA Repair
Genome
heterochromatin
histones
Histones - metabolism
Humans
Models, Biological
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Summary:The view of DNA packaging into chromatin as a mere obstacle to DNA repair is evolving. In this review, we focus on histone variants and heterochromatin proteins as chromatin components involved in distinct levels of chromatin organization to integrate them as real players in the DNA damage response (DDR). Based on recent data, we highlight how some of these chromatin components play active roles in the DDR and contribute to the fine-tuning of damage signaling, DNA and chromatin repair. To take into account this integrated view, we revisit the existing access-repair-restore model and propose a new working model involving priming chromatin for repair and restoration as a concerted process. We discuss how this impacts on both genomic and epigenomic stability and plasticity.
Bibliography:http://dx.doi.org/10.1016/j.molcel.2012.06.002
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ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2012.06.002