Prior oral exposure to environmental immunosuppressive chemicals methoxychlor, parathion, or piperonyl butoxide aggravates allergic airway inflammation in NC/Nga mice

• Published in: Toxicology (Amsterdam) Vol. 309; pp. 1 - 8
• Main Authors: Nishino, R, Fukuyama, T, Tajima, Y, Miyashita, L, Watanabe, Y, Ueda, H, Kosaka, T
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 05.07.2013
• Subjects: Administration, Oral; Airways; allergens; Allergic airway inflammation; animal models; Animals; asthma; B-lymphocytes; blood serum; breathing; Bronchitis - chemically induced; Bronchitis - immunology; Bronchitis - pathology; chemokines; Counting; Cytokines; Emergency; environmental exposure; Environmental Exposure - adverse effects; eosinophils; Exposure; Female; gene expression; hypersensitivity; Hypersensitivity - etiology; Hypersensitivity - immunology; Hypersensitivity - pathology; immunoglobulin E; Immunosuppression; Immunosuppressive Agents - toxicity; inflammation; Inflammation Mediators - toxicity; interleukin-17; Lungs; Lymph; lymph nodes; Methoxychlor; Methoxychlor - administration & dosage; Methoxychlor - toxicity; Mice; oral exposure; ovalbumin; Ovalbumin (OVA); Parathion; Parathion - administration & dosage; Parathion - toxicity; Piperonyl butoxide; Piperonyl Butoxide - toxicity; Random Allocation; respiratory system; rhinitis; Serums; Time Factors; toxicology; Parathion; Piperonyl butoxide; Ovalbumin (OVA); Allergic airway inflammation; Immunosuppression; Methoxychlor
• ISSN: 0300-483X; 1879-3185
• DOI: 10.1016/j.tox.2013.03.018

Highlights • Allergic airway inflammation is aggravated by environmental chemicals methoxychlor, parathion, or piperonylbutoxide. • We investigated the association between immunosuppressive chemicals and development of allergic airway inflammation. • Using an animal model of ovalbumin-induced allergic airway inflammation in NC/Nga mice.