High birth weight as an important risk factor for infant leukemia

In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR...

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Bibliographic Details
Published inBritish journal of cancer Vol. 98; no. 3; pp. 664 - 667
Main Authors KOIFMAN, S, POMBO-DE-OLIVEIRA, M. S
Format Journal Article
LanguageEnglish
Published Basingstoke Nature Publishing Group 12.02.2008
Subjects
Biological and medical sciences
Birth Weight
Epidemiology
Humans
Infant
Infant, Newborn
Leukemia - epidemiology
Medical sciences
Odds Ratio
Risk Factors
Tumors
Brazil
Human
intrauterine factors
infant acute leukaemia
Cancerology
Risk factor
Gene rearrangement
Acute leukemia
Infant
Birth weight
MLL rearrangements
Epidemiology
In utero
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Summary:In this paper, we compared the birth weight distribution among 201 infant leukaemia (IL) cases with that of 440 noncancer controls enrolled in Brazil in 1999-2005. Compared with the general population and the stratum 2500-2999 g as reference, IL cases weighing 3000-3999 g presented an odds ratio (OR) of 1.68 (95% CI: 1.03-2.76), and those of 4000 g or more, an OR of 2.28 (95% CI: 1.08-4.75), P trend<0.01. Using hospital-based controls, the OR for 4000 g or more, compared to 2500-2999 g, was 1.30 (95% CI: 1.02-1.43) after adjusting for confounders (gender, income, maternal age, pesticide and hormonal exposure during pregnancy). The results suggest that high birth weight is associated with increased risk of IL.
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Members and affiliations of the Brazilian Collaborative Study Group of Infant Acute Leukemia (BCSGIAL) are listed in the appendix as co-authors.
ISSN:0007-0920
1532-1827
DOI:10.1038/sj.bjc.6604202