Maladaptive connectivity of Broca’s area in schizophrenia during audiovisual speech perception: An fMRI study

• Published in: Neuroscience Vol. 253; pp. 274 - 282
• Main Authors: Szycik, G.R, Ye, Z, Mohammadi, B, Dillo, W, te Wildt, B.T, Samii, A, Frieling, H, Bleich, S, Münte, T.F
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 03.12.2013; Elsevier
• Subjects: Acoustic Stimulation; Adult; Adult and adolescent clinical studies; audiovisual integration; Biological and medical sciences; Brain Mapping; Female; Frontal Lobe - blood supply; Frontal Lobe - physiopathology; functional connectivity; Fundamental and applied biological sciences. Psychology; General Adaptation Syndrome - etiology; Humans; Image Processing, Computer-Assisted; Magnetic Resonance Imaging; Male; Medical sciences; Middle Aged; multimodal processing; Neurology; Oxygen - blood; Photic Stimulation; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Psychoses; Schizophrenia; Schizophrenia - complications; speech perception; Speech Perception - physiology; Vertebrates: nervous system and sense organs; Visual Perception - physiology; basal ganglia; RpSTS; BG; schizophrenia patients; blood-oxygen-level-dependent; IFG; schizophrenia; analysis of variance; ANOVA; FDR; THL; BOLD; IC; insular cortex; false discovery rate; healthy controls; SP; audiovisual integration; thalamus; inferior frontal gyrus; SMA; multimodal processing; audiovisual; speech perception; echo planar imaging; fMRI; supplementary motor area; functional connectivity; AV; HC; right posterior superior temporal sulcus; functional magnetic resonance imaging; EPI; Psychosis; Schizophrenia; Speech; Perception; Audiovisual integration; Nuclear magnetic resonance imaging; Functional imaging
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.08.041

Highlights • Difference in connectivity of Broca’s area between schizophrenia and control group. • Broca’s connectivity differs between groups for congruent and incongruent speech. • Patient group shows less differentiated connectivity between both conditions.