The Macrophage Iron Signature in Health and Disease

• Published in: International journal of molecular sciences Vol. 22; no. 16; p. 8457
• Main Authors: Mertens, Christina, Marques, Oriana, Horvat, Natalie K., Simonetti, Manuela, Muckenthaler, Martina U., Jung, Michaela
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 06.08.2021; MDPI
• Subjects: Aging; Blood; Cytokines; disordered iron metabolism; Enzymes; Erythrocytes; External stimuli; Genotype & phenotype; Hemoglobin; Homeostasis; Inflammation; Iron; iron metabolism; macrophage polarization; Macrophages; Metabolism; Microorganisms; Proteins; Review; Tumor necrosis factor-TNF

Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, and repair functions by responding to internal and external st...