The Macrophage Iron Signature in Health and Disease

Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, and repair functions by responding to internal and external st...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 16; p. 8457
Main Authors Mertens, Christina, Marques, Oriana, Horvat, Natalie K., Simonetti, Manuela, Muckenthaler, Martina U., Jung, Michaela
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 06.08.2021
MDPI
Subjects
Aging
Blood
Cytokines
disordered iron metabolism
Enzymes
Erythrocytes
External stimuli
Genotype & phenotype
Hemoglobin
Homeostasis
Inflammation
Iron
iron metabolism
macrophage polarization
Macrophages
Metabolism
Microorganisms
Proteins
Review
Tumor necrosis factor-TNF
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Summary:Throughout life, macrophages are located in every tissue of the body, where their main roles are to phagocytose cellular debris and recycle aging red blood cells. In the tissue niche, they promote homeostasis through trophic, regulatory, and repair functions by responding to internal and external stimuli. This in turn polarizes macrophages into a broad spectrum of functional activation states, also reflected in their iron-regulated gene profile. The fast adaptation to the environment in which they are located helps to maintain tissue homeostasis under physiological conditions.
Bibliography:ObjectType-Article-2
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22168457