Sonic Hedgehog gets another role

A study in this issue finds that the chemoattractant cue, Sonic Hedgehog, can activate a repulsive response of commissural axonal pathfinding to Semaphorins, thereby acting as a 'switch' in axon guidance.

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Bibliographic Details
Published inNature neuroscience Vol. 13; no. 1; pp. 6 - 7
Main Author Krull, Catherine E
Format Journal Article
LanguageEnglish
Published New York Nature Publishing Group US 01.01.2010
Nature Publishing Group
Subjects
631/378/1697
631/378/2571/2576
631/80/86
Animal Genetics and Genomics
Animals
Axons
Axons - physiology
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Embryonic Development
Genetic aspects
Hedgehog Proteins - physiology
Motor Neurons - cytology
Motor Neurons - physiology
Neurobiology
Neurosciences
news-and-views
Physiological aspects
Semaphorins
Sonic hedgehog
Spinal Cord - cytology
Spinal Cord - embryology
United States
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Summary:A study in this issue finds that the chemoattractant cue, Sonic Hedgehog, can activate a repulsive response of commissural axonal pathfinding to Semaphorins, thereby acting as a 'switch' in axon guidance.
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ISSN:1097-6256
1546-1726
DOI:10.1038/nn0110-6