Structural perspective on the formation of ribonucleoprotein complex in negative-sense single-stranded RNA viruses

• Published in: Trends in microbiology (Regular ed.) Vol. 21; no. 9; pp. 475 - 484
• Main Authors: Zhou, Honggang, Sun, Yuna, Guo, Yu, Lou, Zhiyong
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.09.2013
• Subjects: Animals; antiviral agents; antiviral drugs; crystallography; electron microscopy; formation; Humans; Internal Medicine; negative-sense single-stranded RNA virus; nucleoproteins; ribonucleoprotein complex; ribonucleoproteins; Ribonucleoproteins - chemistry; Ribonucleoproteins - genetics; Ribonucleoproteins - metabolism; RNA; RNA Viruses - chemistry; RNA Viruses - genetics; RNA Viruses - metabolism; RNA, Viral - chemistry; RNA, Viral - genetics; RNA, Viral - metabolism; structure; Viral Proteins - chemistry; Viral Proteins - genetics; Viral Proteins - metabolism; Virus Diseases - drug therapy; Virus Diseases - virology; virus replication; viruses; antiviral drugs; formation; ribonucleoprotein complex; structure; negative-sense single-stranded RNA virus
• ISSN: 0966-842X; 1878-4380
• DOI: 10.1016/j.tim.2013.07.006

Highlights • Ribonucleoprotein (RNP) plays essential roles in the life cycles of negative-sense single-stranded RNA viruses (NSRVs). • RNP formation in NSRVs has different molecular mechanisms. • Viral nucleoprotein can have enzymatic activities beyond RNA encapsidation. • Blockage of RNP formation provides great potential for antiviral development.