Natriorexigenic effect of DAMGO is decreased by blocking AT1 receptors in the central nucleus of the amygdala

• Published in: Neuroscience Vol. 262; pp. 9 - 20
• Main Authors: Yan, J.-B, Sun, H.-L, Wang, Q, Chen, K, Sun, B, Song, L, Yan, W, Zhao, X.-L, Zhao, S.-R, Zhang, Y, Qiao, H, Hu, B, Yan, J.-Q
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 14.03.2014; Elsevier
• Subjects: Amygdala - drug effects; Amygdala - metabolism; Analgesics, Opioid - pharmacology; angiotensin II; Angiotensin II Type 1 Receptor Blockers - pharmacology; Angiotensin-Converting Enzyme Inhibitors - pharmacology; Animals; Biological and medical sciences; Captopril - pharmacology; Diuretics - pharmacology; Drinking Behavior - drug effects; Enkephalin, Ala-MePhe-Gly- - pharmacology; Fundamental and applied biological sciences. Psychology; Furosemide - pharmacology; losartan; Losartan - pharmacology; Male; Neurology; Rats; Rats, Sprague-Dawley; Receptor, Angiotensin, Type 1 - metabolism; sodium appetite; Sodium Chloride, Dietary - administration & dosage; the central nucleus of the amygdale; Time Factors; Vertebrates: nervous system and sense organs; Water; Water Deprivation; μ-opioid receptors; the central nucleus of the amygdale; angiotensin-converting enzyme inhibitor captopril; DAMGO; WD–PR; lateral parabrachial nucleus; NTS; ANG II; [D-Ala 2, N-Me-Phe 4, Gly 5-ol]-enkephalin; central nucleus of the amygdala; analysis of variance; ANOVA; water deprivation–partial rehydration; losartan; AT1; sodium appetite; inhibitory post-synaptic currents; MnPO; diuretic furosemide; nucleus of the solitary tract; anterior hypothalamic area; μ-ORs; FURO; median preoptic nucleus; CAP; LPBN; ANG II type 1; angiotensin II; IPSCs; μ-opioid receptors; AHA; CeA; Appetite; Amygdala; Central nervous system; μ Opioid receptor; Basal ganglion; AT1 angiotensin receptor; Encephalon; Renin angiotensin system; Sodium; Losartan; Angiotensin II
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.12.046

Highlights • Intra-CeA losartan suppressed sodium intake induced by intra-CeA DAMGO in WD–PR rats. • Intra-CeA losartan reduced sodium intake induced by intra-CeA DAMGO in FURO/CAP rats. • Natriorexigenic effect of DAMGO is reduced by AT1 receptor blockade in the CeA.