Effect of melatonin on motor performance and brain cortex mitochondrial function during ethanol hangover

• Published in: Neuroscience Vol. 269; pp. 281 - 289
• Main Authors: Karadayian, A.G, Bustamante, J, Czerniczyniec, A, Cutrera, R.A, Lores-Arnaiz, S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 06.06.2014; Elsevier
• Subjects: Alcohol-Related Disorders - drug therapy; Alcohol-Related Disorders - physiopathology; Animals; Antioxidants - pharmacology; Biological and medical sciences; Central Nervous System Depressants - adverse effects; Cerebral Cortex - drug effects; Cerebral Cortex - physiopathology; Ethanol - adverse effects; ethanol hangover; Fundamental and applied biological sciences. Psychology; Hydrogen Peroxide - metabolism; Male; melatonin; Melatonin - pharmacology; Membrane Potential, Mitochondrial - drug effects; Membrane Potential, Mitochondrial - physiology; Mice; Mitochondria - drug effects; Mitochondria - physiology; mitochondrial function; mitochondrial membrane potential; Motor Activity - drug effects; Motor Activity - physiology; Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration; motor coordination; Neurology; Nitric Oxide Synthase Type I - metabolism; Nitric Oxide Synthase Type II - metabolism; Nitrogen Oxides - metabolism; oxidative stress; Oxygen - metabolism; Vertebrates: nervous system and sense organs; RCR; NO; Hydrogen peroxide; Nω-nitro- l-arginine; HRP; respiratory control ratio; FCCP; blood alcohol concentration; Inducible nitric oxide synthase; ethylenediaminetetraacetic acid; horseradish peroxidase; iNOS; superoxide anion; motor coordination; O 2; nitric oxide; mitochondrial function; BAC; l-NNA; mitochondrial membrane potential; ethanol hangover; neuronal nitric oxide synthase; SOD; 3,3″-dihexyloxacarbocyanine iodide; EDTA; hydroxyethyl piperazineethanesulfonic acid; EGTA; H 2O 2; voltage-dependent anion channel; HEPES; superoxide dismutase; nNOS; VDAC; DiOC 6; carbonyl cyanide p-trifluoromethoxyphenylhydrazone; ethylene glycol tetraacetic acid; melatonin; oxidative stress; O2; H2O2; DiOC6; Oxidative stress; Cerebral cortex; Melatonin; Motor pathway; Ethanol; Central nervous system; Electrophysiology; Motor control; Encephalon; Mitochondria; Motor cortex; Membrane potential; Pineal hormone
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.03.062

Highlights • A weekly exposure to melatonin improved motor coordination during hangover in mice. • Melatonin reduced free radical production and prevented mitochondrial transmembrane collapse. • Melatonin induced an impairment of the respiratory chain probably due to changes in NO metabolism.