The amnesic effect of intra-central amygdala administration of a cannabinoid CB1 receptor agonist, WIN55,212-2, is mediated by a beta-1 noradrenergic system in rat

• Published in: Neuroscience Vol. 212; pp. 77 - 85
• Main Authors: Zarrindast, M.R, Ghiasvand, M, Rezayof, A, Ahmadi, S
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 14.06.2012; Elsevier
• Subjects: Amnesia; Amnesia - chemically induced; Amnesia - metabolism; Amnesia - physiopathology; Amygdala; Amygdala - drug effects; Amygdala - physiology; Animals; Atenolol; Benzoxazines - pharmacology; Biological and medical sciences; Cannabinoid CB1 receptors; cannabinoid receptor; Cannabinoid Receptor Modulators - pharmacology; central amygdala; Drugs; Fundamental and applied biological sciences. Psychology; isoprenaline; Male; Medical sciences; Memory; Memory - drug effects; Memory - physiology; Morpholines - pharmacology; Naphthalenes - pharmacology; Nervous system; Neurology; Neuropharmacology; Norepinephrine; Pharmacology. Drug treatments; Psychodysleptics: hallucinogen; Psychology. Psychoanalysis. Psychiatry; Psychopharmacology; rat; Rats; Rats, Wistar; Receptor, Cannabinoid, CB1 - agonists; Receptors, Adrenergic, beta-1 - physiology; Vertebrates: nervous system and sense organs; norepinephrine; VTA; medial prefrontal cortex; rat; inhibitory avoidance; cannabinoid receptor; locus coeruleus; mPFC; amnesia; ventral tegmental area; BLA; atenolol; central amygdala; LC; NE; IA; basolateral amygdala; CeA; isoprenaline; CB1 cannabinoid receptor; Agonist; Isoprenaline; Amygdala; Rat; Rodentia; Central nervous system; Basal ganglion; Atenolol; Encephalon; Vertebrata; Mammalia; Animal; Cannabinoid receptor
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2012.04.008

Highlights ► Post-training intra-CeA injections of WIN55,212-2 induced amnesia. ► Isoprenaline prevented while atenolol increased the impairing effect of WIN55,212-2. ► Atenolol prevented the improving effect of isoprenaline on WIN55,212-2 response. ► Adrenoceptors in the CeA are indirectly involved in amnesia induced by WIN55,212-2.