Cyanine dye mediated mitochondrial targeting enhances the anti-cancer activity of small-molecule cargoes

Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold. Con...

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Published inChemical communications (Cambridge, England) Vol. 56; no. 34; pp. 4672 - 4675
Main Authors Nödling, Alexander R, Mills, Emily M, Li, Xuefei, Cardella, Davide, Sayers, Edward J, Wu, Shih-Hsiung, Jones, Arwyn T, Luk, Louis Y. P, Tsai, Yu-Hsuan
Format Journal Article
LanguageEnglish
Published England Royal Society of Chemistry 30.04.2020
Subjects
Anticancer properties
antineoplastic activity
Antineoplastic Agents - administration & dosage
Antineoplastic Agents - chemistry
Carbocyanines - administration & dosage
Carbocyanines - chemistry
Carbonyl Cyanide m-Chlorophenyl Hydrazone - administration & dosage
Carbonyl Cyanide m-Chlorophenyl Hydrazone - chemistry
Cell Line
Cell Survival - drug effects
chemical compounds
chemical reactions
Conjugation
Cyanine dyes
cytotoxicity
dyes
Fluorescent Dyes - administration & dosage
Fluorescent Dyes - chemistry
Humans
Mitochondria
Mitochondria - metabolism
neoplasm cells
neoplasms
Toxicity
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Summary:Organelle-specific delivery systems are of significant clinical interest. We demonstrate the use of common cyanine dyes Cy3 and Cy5 as vectors for targeting and delivering cargoes to mitochondria in cancer cells. Specifically, conjugation to the dyes can increase cytotoxicity by up to 1000-fold. Conjugation of small molecules to a simple cyanine dye can lead to organelle-specific delivery.
Bibliography:Electronic supplementary information (ESI) available: Experimental procedures, characterisation of compounds. See DOI
10.1039/c9cc07931a
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SourceType-Scholarly Journals-1
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ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/c9cc07931a