Low dose of lipopolysaccharide pretreatment can alleviate the inflammatory response in wound infection mouse model
Purpose： To assess the effects of lipopolysaccharide （LPS） pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. Methods： Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision w...
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| Published in | Chinese journal of traumatology Vol. 19; no. 4; pp. 193 - 198 |
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| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
China
Elsevier B.V
01.08.2016
Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China Elsevier |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-1275 |
| DOI | 10.1016/j.cjtee.2016.06.001 |
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| Abstract | Purpose： To assess the effects of lipopolysaccharide （LPS） pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. Methods： Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision was made and infected with different bacteria. Results： It is showed that 0.5 mg/kg/time ofLPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa, or Escherichia coil compared with doses of 0.25 mg/kg/time, 1 mg/ kg/time, and 1.5 mg/kg/time. Conclusions： LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs＇ function. |
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| AbstractList | To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo.
Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial longitudinal incision was made and infected with different bacteria.
It is showed that 0.5 mg/kg/time of LPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa, or Escherichia coli compared with doses of 0.25 mg/kg/time, 1 mg/kg/time, and 1.5 mg/kg/time.
LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs' function. Purpose： To assess the effects of lipopolysaccharide （LPS） pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. Methods： Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision was made and infected with different bacteria. Results： It is showed that 0.5 mg/kg/time ofLPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa, or Escherichia coil compared with doses of 0.25 mg/kg/time, 1 mg/ kg/time, and 1.5 mg/kg/time. Conclusions： LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs＇ function. Purpose: To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. Methods: Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial longitudinal incision was made and infected with different bacteria. Results: It is showed that 0.5 mg/kg/time of LPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa, or Escherichia coli compared with doses of 0.25 mg/kg/time, 1 mg/kg/time, and 1.5 mg/kg/time. Conclusions: LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs' function. Purpose:To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo.Methods:Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial longitudinal incision was made and infected with different bacteria.Results:It is showed that 0.5 mg/kg/time of LPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus,methicillin-sensitive S.aureus,Pseudomonas aeruginosa,or Escherichia coli compared with doses of 0.25 mg/kg/time,1 mg/kg/time,and 1.5 mg/kg/time.Conclusions:LP5 pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time,and meanwhile it does not damage organs' function. |
| Author | DongWang Yang Liu Yan-Rui Zhao Jun-Lin Zhou |
| AuthorAffiliation | Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China |
| AuthorAffiliation_xml | – name: Department of Orthopedics, Beijing Chao-Yang Hospital, Beijing 100020, China |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/28935116$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1007/978-3-319-11038-7_2 10.2147/DDDT.S71957 10.1016/j.ecoenv.2013.09.039 10.1098/rsif.2010.0294 10.1007/978-1-4419-0298-6_23 10.1016/j.ijfoodmicro.2011.12.035 10.3389/fimmu.2013.00109 10.7603/s40681-015-0005-x 10.1021/jf505531w 10.1097/SHK.0b013e318162c190 10.3855/jidc.4482 10.4103/0972-124X.107466 10.1371/journal.pone.0124001 10.1002/pros.22983 10.1128/IAI.68.6.3748-3753.2000 10.1007/s00268-014-2922-3 10.2106/JBJS.K.01672 10.1517/14712598.2013.838556 |
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| Keywords | Surgical wound infection Inflammatory reaction Lipopolysaccharides |
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| Notes | Purpose： To assess the effects of lipopolysaccharide （LPS） pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment dose in vivo. Methods： Mice were pretreated with LPS of different doses at 48 and 24 h before femoral medial lon- gitudinal incision was made and infected with different bacteria. Results： It is showed that 0.5 mg/kg/time ofLPS pretreatment can significantly alleviate the inflammation in mouse model infected with methicillin-resistances Staphylococcus aureus, methicillin-sensitive S. aureus, Pseudomonas aeruginosa, or Escherichia coil compared with doses of 0.25 mg/kg/time, 1 mg/ kg/time, and 1.5 mg/kg/time. Conclusions： LPS pretreatment can alleviate the inflammation in mouse model and the optimal dose is 0.5 mg/kg/time, and meanwhile it does not damage organs＇ function. Lipopolysaccharides;Inflammatory reaction;Surgical wound infection 50-1115/R |
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| Snippet | Purpose： To assess the effects of lipopolysaccharide （LPS） pretreatment on wound infection mouse model and evaluate the biological safety of the optimal... To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal pretreatment... Purpose:To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal... Purpose: To assess the effects of lipopolysaccharide (LPS) pretreatment on wound infection mouse model and evaluate the biological safety of the optimal... |
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| SubjectTerms | Animals Disease Models, Animal Female Inflammation - prevention & control Inflammatory reaction Lipopolysaccharides Lipopolysaccharides - therapeutic use Mice Mice, Inbred BALB C Rats Rats, Wistar Surgical wound infection Surgical Wound Infection - drug therapy Toll-Like Receptor 4 - physiology |
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| Title | Low dose of lipopolysaccharide pretreatment can alleviate the inflammatory response in wound infection mouse model |
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