Stromal cells can contribute oncogenic signals

The majority of studies of neoplastic transformation have focused attention on events that occur within transformed cells. These cell autonomous events result in the disruption of molecular pathways that regulate basic activities of the cells such as proliferation, death, movement and genomic integr...

Full description

Saved in:
Bibliographic Details
Published inSeminars in cancer biology Vol. 11; no. 2; pp. 97 - 104
Main Author Tlsty, Thea D
Format Journal Article
LanguageEnglish
Published Legacy CDMS Elsevier Ltd 01.04.2001
Subjects
Animals
carcinogenesis / genomic instability / stromal–epithelial interactions / carcinoma-associated fibroblasts / reactive stroma
Humans
Life Sciences (General)
Male
Neoplasms - drug therapy
Neoplasms - metabolism
Neoplasms - pathology
Signal Transduction - physiology
Space life sciences
Stromal Cells - physiology
carcinogenesis / genomic instability / stromal–epithelial interactions / carcinoma-associated fibroblasts / reactive stroma
Non-Nasa Center
Nasa Discipline Radiation Health
Review
Review, Tutorial
NASA Discipline Radiation Health
Non-NASA Center
Online AccessGet full text

Cover

More Information
Summary:The majority of studies of neoplastic transformation have focused attention on events that occur within transformed cells. These cell autonomous events result in the disruption of molecular pathways that regulate basic activities of the cells such as proliferation, death, movement and genomic integrity. Other studies have addressed the microenvironment of tumor cells and documented its importance in supporting tumor progression. Recent work has begun to expand on these initial studies of tumor microenvironment and now provide novel insights into the possible initiation and progression of malignant cells. This review will address the transforming effect of stromal cells on epithelial components.
Bibliography:CDMS
Legacy CDMS
ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-1
ObjectType-Review-3
content type line 23
ObjectType-Article-1
ObjectType-Feature-3
ObjectType-Review-2
ISSN:1044-579X
1096-3650
DOI:10.1006/scbi.2000.0361