Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features

Abstract The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of c...

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Published inLeukemia research Vol. 36; no. 3; pp. 293 - 298
Main Authors de Oliveira, Jaqueline Carvalho, Scrideli, Carlos Alberto, Brassesco, María Sol, Morales, Andressa Gois, Pezuk, Julia Alejandra, Queiroz, Rosane de Paula, Yunes, José Andres, Brandalise, Silvia Regina, Tone, Luiz Gonzaga
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.03.2012
Subjects
Adolescent
Case-Control Studies
Child
Child, Preschool
Chromosomes, Human, Pair 12 - genetics
Chromosomes, Human, Pair 21 - genetics
Female
Gene Expression Profiling
Hematology, Oncology and Palliative Medicine
Humans
Infant
Infant, Newborn
Leukocyte Count
Male
MicroRNA
MicroRNAs - genetics
Neoplasm Staging
Neoplasm, Residual - genetics
Neoplasm, Residual - pathology
Pediatric acute lymphoblastic leukemia
Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor Cell Lymphoblastic Leukemia-Lymphoma - pathology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology
Prognosis
Prognostic features
Real-Time Polymerase Chain Reaction
Reverse Transcriptase Polymerase Chain Reaction
Translocation, Genetic - genetics
Pediatric acute lymphoblastic leukemia
MicroRNA
Prognostic features
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Summary:Abstract The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t (12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology.
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ISSN:0145-2126
1873-5835
DOI:10.1016/j.leukres.2011.10.005