The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating...

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Published inMolecular therapy. Nucleic acids Vol. 26; pp. 1270 - 1279
Main Authors Chen, Zuyao, Zhong, Xiaolin, Xia, Min, Zhong, Jing
Format Journal Article
LanguageEnglish
Published Elsevier Inc 03.12.2021
American Society of Gene & Cell Therapy
Elsevier
Subjects
m6A
mRNA stability
N6-methyladenosine
protein translation
Review
tumor biology
YTHDF1
protein translation
m6A
tumor biology
YTHDF1
N6-methyladenosine
mRNA stability
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Abstract YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases. [Display omitted] YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating different target genes.
AbstractList YTHDF1 is the most versatile and powerful reader protein of N 6 -methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases. YTHDF1 is the most versatile and powerful reader protein of N 6 -methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating different target genes.
YTHDF1 is the most versatile and powerful reader protein of N 6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.YTHDF1 is the most versatile and powerful reader protein of N 6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.
YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases. [Display omitted] YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating different target genes.
YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases.
Author Chen, Zuyao
Zhong, Jing
Xia, Min
Zhong, Xiaolin
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  surname: Chen
  fullname: Chen, Zuyao
  organization: Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China
– sequence: 2
  givenname: Xiaolin
  surname: Zhong
  fullname: Zhong, Xiaolin
  organization: Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China
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  givenname: Min
  surname: Xia
  fullname: Xia, Min
  organization: Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China
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  givenname: Jing
  orcidid: 0000-0003-4593-4897
  surname: Zhong
  fullname: Zhong, Jing
  email: zhongjing2002@usc.edu.cn
  organization: Hengyang Medical School, University of South China, 421001 Hengyang, Hunan, China
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Keywords protein translation
m6A
tumor biology
YTHDF1
N6-methyladenosine
mRNA stability
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Snippet YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as...
YTHDF1 is the most versatile and powerful reader protein of N 6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as...
YTHDF1 is the most versatile and powerful reader protein of N 6 -methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as...
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SubjectTerms m6A
mRNA stability
N6-methyladenosine
protein translation
Review
tumor biology
YTHDF1
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Title The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases
URI https://dx.doi.org/10.1016/j.omtn.2021.10.023
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