The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases

• Published in: Molecular therapy. Nucleic acids Vol. 26; pp. 1270 - 1279
• Main Authors: Chen, Zuyao, Zhong, Xiaolin, Xia, Min, Zhong, Jing
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 03.12.2021; American Society of Gene & Cell Therapy; Elsevier
• Subjects: m6A; mRNA stability; N6-methyladenosine; protein translation; Review; tumor biology; YTHDF1; protein translation; m6A; tumor biology; YTHDF1; N6-methyladenosine; mRNA stability
• ISSN: 2162-2531; 2162-2531
• DOI: 10.1016/j.omtn.2021.10.023

YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A)-modified RNA, and it can recognize both G(m6A)C and A(m6A)C RNAs as ligands without sequence selectivity. YTHDF1 regulates target gene expression by different mechanisms, such as promoting translation or regulating the stability of mRNA. Numerous studies have shown that YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating the protein translation of important genes or by affecting the expression of key factors involved in many important cell signaling pathways. Therefore, in this review we focus on some of the roles of YTHDF1 in tumor biology and diseases. [Display omitted] YTHDF1 is the most versatile and powerful reader protein of N6-methyladenosine (m6A). YTHDF1 regulates target gene expression by promoting translation or regulating the stability of mRNA. YTHDF1 plays an important role in tumor biology and nontumor lesions by mediating different target genes.