Differential effects of retinal degeneration on sleep and wakefulness responses to short light–dark cycles in albino mice

• Published in: Neuroscience Vol. 248; pp. 459 - 468
• Main Authors: Hsiao, F.-C, Liao, Y.-H, Tsai, L.-L
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 17.09.2013; Elsevier
• Subjects: Age Factors; Animals; Biological and medical sciences; Chronobiology; Circadian Rhythm; dark pulse; Darkness; Electroencephalography; Fundamental and applied biological sciences. Psychology; Light; Male; melanopsin; Mice; Mice, Inbred Strains; Neurology; Photoperiod; positive masking; rapid-eye-movement sleep; Retinal Degeneration - physiopathology; Sleep; Sleep. Vigilance; Species Specificity; Time Factors; Vertebrates: anatomy and physiology, studies on body, several organs or systems; Vertebrates: nervous system and sense organs; Wakefulness; waking; paradoxical sleep; rapid-eye-movement sleep; PS; EEG; non-rapid eye movement sleep; wakefulness; electroencephalogram; electromyogram; melanopsin; Friend Virus B type; FVB; dark pulse; NREMS; W; circadian rhythm; LD; light–dark; waking; ICR; Institute for Cancer Research; positive masking; EMG; Rodentia; Retina; Biological rhythm; Circadian rhythm; Rapid eye movement sleep; Melanopsin; Eye; Visual system; Vertebrata; Mammalia; Mouse; Animal; Pigments; Degeneration; Masking; waking, positive masking
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.06.033

Highlights • Genetic rd mutation and bright light reduced photoreceptors in the outer retina. • Photoreceptor loss in the outer retina did not alter REM sleep increases in the dark. • Photoreceptor loss in the outer retina did not alter NREM sleep increases in the light. • The rd mutation enhanced the suppressing effect of the dark on wakefulness. • Light-induced retinal degeneration enhanced the alerting effect of light.