Induction of S100A4 in periodontal ligament cells enhances osteoclast formation

Highlights • S100A4 was induced in human periodontal ligament cells by inflammatory stimuli LPS. • NFκb signaling pathway mediated the S100A4 up-regulation in hPDL cells. • LPS-treated hPDL cells enhanced osteoclastogenesis from primary progenitor cells. • Recombinant S100A4 directly stimulated oste...

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Published inArchives of oral biology Vol. 60; no. 9; pp. 1215 - 1221
Main Authors Mah, Su-jung, Lee, Jiyeon, Kim, Haemin, Kang, Yoon-Goo, Baek, Seung-Hak, Kim, Hong-Hee, Lim, Won Hee
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.09.2015
Subjects
Advanced Basic Science
Blotting, Western
Coculture Techniques
Dentistry
Humans
Inflammation
Lipopolysaccharides
NF-kappa B - metabolism
NFκB
Osteoclastogenesis
Osteoclasts - metabolism
Periodontal Ligament - cytology
Periodontal ligament cells
Real-Time Polymerase Chain Reaction
S100 Calcium-Binding Protein A4
S100 Proteins - metabolism
S100A4
Up-Regulation
Osteoclastogenesis
S100A4
Inflammation
Periodontal ligament cells
NFκB
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Summary:Highlights • S100A4 was induced in human periodontal ligament cells by inflammatory stimuli LPS. • NFκb signaling pathway mediated the S100A4 up-regulation in hPDL cells. • LPS-treated hPDL cells enhanced osteoclastogenesis from primary progenitor cells. • Recombinant S100A4 directly stimulated osteoclastogenesis. • Our data suggest that S100A4 may contribute to bone destruction in periodontitis.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0003-9969
1879-1506
DOI:10.1016/j.archoralbio.2015.05.014