Association study between epidermal growth factor receptor and epidermal growth factor polymorphisms and endometriosis in a Japanese population

• Published in: Gynecological endocrinology Vol. 23; no. 8; pp. 474 - 478
• Main Authors: Inagaki, Mieko, Yoshida, Shigeki, Kennedy, Stephen, Takemura, Naoya, Deguchi, Masashi, Ohara, Noriyuki, Maruo, Takeshi
• Format: Journal Article
• Language: English
• Published: England Informa UK Ltd 2007; Taylor & Francis; Taylor & Francis Ltd
• Subjects: Adult; Amplified Fragment Length Polymorphism Analysis; Asian Continental Ancestry Group - genetics; Chi-Square Distribution; Endometriosis; Endometriosis - genetics; epidermal growth factor; Epidermal Growth Factor - genetics; epidermal growth factor receptor; Female; Gene Frequency; gene polymorphism; Genetic Association Studies; Genetic Predisposition to Disease; Humans; Infant, Newborn; Japan; Odds Ratio; polymerase chain reaction; Polymorphism, Restriction Fragment Length - genetics; Receptor, Epidermal Growth Factor - genetics; restriction fragment length polymorphism; Severity of Illness Index; Japan
• ISSN: 0951-3590; 1473-0766
• DOI: 10.1080/09513590701521057

Objective. We investigated a possible association between endometriosis and polymorphisms in the genes encoding epidermal growth factor (EGF) receptor (EGFR) and EGF in a Japanese population. Methods. We compared the distribution of the Egfr+2073 A T and Egf+61 G A polymorphisms by polymerase chain reaction-restriction fragment length polymorphism analysis in 146 affected women and 181 controls. Results. No significant differences in the frequency and genotype distribution of the Egfr+2073 A T and Egf+61 G A polymorphisms were found between endometriosis patients with all disease stages and controls. Stratification by disease stage had no effect on the results. Conclusion. The Egfr+2073 A T and Egf+61 G A polymorphisms are not associated with an increased risk of endometriosis in a Japanese population.