Functional and effective connectivity in subthalamic local field potential recordings of patients with Parkinson’s disease

• Published in: Neuroscience Vol. 250; pp. 320 - 332
• Main Authors: Hohlefeld, F.U, Huchzermeyer, C, Huebl, J, Schneider, G.-H, Nolte, G, Brücke, C, Schönecker, T, Kühn, A.A, Curio, G, Nikulin, V.V
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 10.10.2013; Elsevier
• Subjects: Aged; Algorithms; Antiparkinson Agents - therapeutic use; basal ganglia; Beta Rhythm; Biological and medical sciences; coherency; Data Interpretation, Statistical; Deep Brain Stimulation; Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases; Dopamine Agents - therapeutic use; Electroencephalography; Evoked Potentials - physiology; Female; Humans; levodopa; Levodopa - therapeutic use; Male; Medical sciences; Middle Aged; Nervous system (semeiology, syndromes); Nervous system as a whole; Neural Pathways - physiology; Neurology; neuronal oscillations; Parkinson Disease - drug therapy; Parkinson Disease - physiopathology; Psychomotor Performance - drug effects; Subthalamic Nucleus - physiology; basal ganglia; coherence; STN; imaginary part of coherence; DBS; levodopa; LFP; UPDRS; COH; phase–slope index; iCOH sigav; jackknife significance of iCOH; iCOH; PSI; local field potentials; neuronal oscillations; deep brain stimulation; averaged jackknife significance of iCOH; PD; iCOH sig; subthalamic nucleus; coherency; Unified Parkinson’s Disease Rating Scale; jackknife significance of PSI; Parkinson’s disease; PSI sig; iCOHsig; PSIsig; iCOHsigav; Human; Nervous system diseases; Deep brain stimulation; Central nervous system; Electrophysiology; Parkinson disease; Basal ganglion; Antiparkinson agent; Encephalon; Cerebral disorder; Central nervous system disease; Oscillation; Field potential; Degenerative disease; Levodopa; Extrapyramidal syndrome; PSI(sig); iCOH(sig); iCOH(sigav)
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2013.07.028

Highlights • Regional connectivity in STN–LFP (10–30 Hz) was not due to volume conduction. • Functional connectivity was increased in the levodopa ON condition. • The levodopa OFF–ON changes in connectivity correlated with UPDRS scores. • Complex connectivity patterns may have implications for spatial specificity of DBS.