PEGylated graphene oxide for tumor-targeted delivery of paclitaxel

The graphene oxide (GO) sheet has been considered one of the most promising carbon derivatives in the field of material science for the past few years and has shown excellent tumor-targeting ability, biocompatibility and low toxicity. We have endeavored to conjugate paclitaxel (PTX) to GO molecule a...

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Bibliographic Details
Published inNanomedicine (London, England) Vol. 10; no. 8; pp. 1247 - 1262
Main Authors Xu, Hongyang, Fan, Minmin, Elhissi, Abdelbary MA, Zhang, Zhirong, Wan, Ka-Wai, Ahmed, Waqar, Phoenix, David A, Sun, Xun
Format Journal Article
LanguageEnglish
Published England Future Medicine Ltd 01.04.2015
Subjects
Analysis
Animals
Antineoplastic Agents, Phytogenic - administration & dosage
Antineoplastic Agents, Phytogenic - pharmacokinetics
Antineoplastic Agents, Phytogenic - therapeutic use
Biocompatibility
Cancer
cancer therapy
Care and treatment
Cell Line, Tumor
Chemotherapy
Diagnosis
Drug Carriers - chemistry
drug delivery
Drug Delivery Systems
Female
graphene oxide
Graphite - chemistry
Health aspects
Inflammation
Melanoma - drug therapy
Melanoma - pathology
Mice
Mice, Inbred C57BL
Oxides - chemistry
paclitaxel
Paclitaxel - administration & dosage
Paclitaxel - pharmacokinetics
Paclitaxel - therapeutic use
Polyethylene Glycols - chemistry
Rats, Wistar
cancer therapy
graphene oxide
paclitaxel
drug delivery
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Summary:The graphene oxide (GO) sheet has been considered one of the most promising carbon derivatives in the field of material science for the past few years and has shown excellent tumor-targeting ability, biocompatibility and low toxicity. We have endeavored to conjugate paclitaxel (PTX) to GO molecule and investigate its anticancer efficacy. We conjugated the anticancer drug PTX to aminated PEG chains on GO sheets through covalent bonds to get GO-PEG-PTX complexes. The tissue distribution and anticancer efficacy of GO-PEG-PTX were then investigated using a B16 melanoma cancer-bearing C57 mice model. The GO-PEG-PTX complexes exhibited excellent water solubility and biocompatibility. Compared with the traditional formulation of PTX (Taxol®), GO-PEG-PTX has shown prolonged blood circulation time as well as high tumor-targeting and -suppressing efficacy. PEGylated graphene oxide is an excellent nanocarrier for paclitaxel for cancer targeting.
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SourceType-Scholarly Journals-1
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ISSN:1743-5889
1748-6963
DOI:10.2217/nnm.14.233