External-Beam Radiotherapy Alone Management of Primary CNS Lymphoplasmacytic Lymphoma: A Vietnamese Case Report and Literature Review

Primary central nervous system (CNS) lymphoma is an uncommon non-Hodgkin disease limited to the CNS, and most cases are diffuse large B-cell lymphomas. Other pathologies, including lymphoplasmacytic lymphoma (LPL), are exceedingly rare and poorly understood. The clinical presentation of primary CNS...

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Bibliographic Details
Published inJournal of blood medicine Vol. 12; pp. 769 - 774
Main Authors Nguyen Van, Dang, Duong Van, Nghia, Le Van, Quang, Ngo Thanh, Tung, Ta Van, To
Format Journal Article
LanguageEnglish
Published New Zealand Dove Medical Press Limited 01.01.2021
Taylor & Francis Ltd
Dove
Dove Medical Press
Subjects
Biopsy
Bone marrow
Care and treatment
Case Report
Chemotherapy
Development and progression
Immunoglobulins
Intracranial pressure
Lymphocytes
Lymphoma
lymphoplasmacytic lymphoma
Magnetic resonance imaging
Non-Hodgkin's lymphomas
Patients
Plasma
primary cns lymphoma
Radiation
Radiation therapy
Radiotherapy
Spinal cord
Tumors
Vietnam
primary CNS lymphoma
lymphoplasmacytic lymphoma
radiation therapy
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Summary:Primary central nervous system (CNS) lymphoma is an uncommon non-Hodgkin disease limited to the CNS, and most cases are diffuse large B-cell lymphomas. Other pathologies, including lymphoplasmacytic lymphoma (LPL), are exceedingly rare and poorly understood. The clinical presentation of primary CNS LPL is diverse. It depends on the original site and the tumor's extension. There is currently no consensus on a treatment strategy for this uncommon manifestation. To our knowledge, no previously published case was successfully treated with radiation therapy alone. We present here a case of primary CNS LPL. A 46-year-old, previously healthy woman was presented with a worsening headache and lower extremity numbness. Multifocal enhanced masses were detected in an MRI with biopsy results consistent with LPL. A complete staging workup was performed with no evidence of systemic disease. The patient received external-beam radiotherapy alone and had a complete remission. After 2 years of follow-up, she remains disease-free. Radiation alone is a promising treatment option for primary CNS lymphoplasmacytic lymphoma.
ISSN:1179-2736
1179-2736
DOI:10.2147/JBM.S326165