A novel combined model of intracerebral and intraventricular hemorrhage using autologous blood-injection in rats

• Published in: Neuroscience Vol. 272; pp. 286 - 294
• Main Authors: Marinkovic, I, Strbian, D, Mattila, O.S, Abo-Ramadan, U, Tatlisumak, T
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier Ltd 11.07.2014; Elsevier
• Subjects: Animals; Biological and medical sciences; Blood Volume - physiology; Brain Edema - etiology; Brain Edema - surgery; Cerebral Hemorrhage - pathology; Cerebral Hemorrhage - surgery; Cerebral Ventricles - pathology; Cerebral Ventricles - surgery; Cerebrospinal fluid. Meninges. Spinal cord; hydrocephalus; Hydrocephalus - pathology; Hydrocephalus - surgery; intracerebral hemorrhage; intraventricular hemorrhage; Magnetic Resonance Imaging; Male; Medical sciences; Nervous system (semeiology, syndromes); Neurology; rat; Rats, Wistar; Vascular diseases and vascular malformations of the nervous system; magnetic resonance imaging; RARE; rat; hydrocephalus; MRI; fast low-angle shot; FLASH; ICH; intracerebral hemorrhage; intraventricular hemorrhage; relaxation enhancement; CSF; cerebrospinal fluid; IVH; Nervous system diseases; Rat; Rodentia; Cardiovascular disease; Nuclear magnetic resonance imaging; Cerebral disorder; Vascular disease; Vertebrata; Mammalia; Animal; Cerebral hemorrhage; Central nervous system disease; Models; Hydrocephaly; Cerebrovascular disease
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2014.05.001

Highlights • Fully novel rat model of ICH with ventricular extension, one week of MRI follow-up. • Brain edema peaking at 48 h after hemorrhage in all groups. • Progressive hydrocephalus in most of the subjects, peaking in ⩾200 μL groups. • Worst neurological outcome in groups injected with ⩾200 μL of autologus blood. • Mortality rate similar to the clinical scenario in ⩾200 μL groups.